Non‐steroidal anti‐inflammatory drugs as a possible cause for reversible infertility

L L F Mendonça; Munther A. Khamashta; Catherine Nelson‐Piercy; Beverley J. Hunt; G R Hughes

doi:10.1093/rheumatology/39.8.880

Non‐steroidal anti‐inflammatory drugs as a possible cause for reversible infertility

L L F Mendonça, Munther A. Khamashta, Catherine Nelson‐Piercy, Beverley J. Hunt, G R Hughes

In: Rheumatology · 2000 · vol. 39(8) , pp. 880–882 · doi:10.1093/rheumatology/39.8.880 · PMID:10952743 · W2123513105

article OA: bronze CC0 ⤵ 8 in-corpus citations

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Four women with arthritis who stopped long-term non-steroidal anti-inflammatory drug (NSAID) use successfully conceived shortly thereafter, suggesting NSAIDs may cause reversible infertility.

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Abstract

OBJECTIVE: To highlight the possible association between infertility and treatment with long-term non-steroidal anti-inflammatory drug (NSAIDs). NSAIDs act mainly through the inhibition of cyclooxygenase, the enzyme that catalyses the synthesis of prostaglandins, which are essential mediators of ovulation, implantation and placentation of the conceptus. METHODS: Case reports of four women suffering from severe arthritis, on long-term NSAIDs and undergoing extensive investigation and treatment for infertility. RESULTS: During the last 2 yr, four out of five women with severe arthritis and difficulty conceiving were counselled to stop NSAIDs, and they successfully conceived shortly after the withdrawal of NSAIDs. CONCLUSION: NSAIDs, used largely for the treatment of rheumatological conditions, may be responsible for some cases of infertility.

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References (7)

doi:10.1007/978-1-4899-0952-7_8 via openalex
W2416117630 via openalex
doi:10.1016/s0015-0282(16)59163-8 via openalex
doi:10.1093/rheumatology/35.1.76 via openalex
doi:10.1016/s0049-0172(97)80046-7 via openalex
doi:10.1093/rheumatology/35.5.458 via openalex
doi:10.1016/s0092-8674(00)80402-x via openalex

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[1] doi:10.1007/978-1-4899-0952-7_8 via openalex

[2] W2416117630 via openalex

[3] doi:10.1016/s0015-0282(16)59163-8 via openalex

[4] doi:10.1093/rheumatology/35.1.76 via openalex

[5] doi:10.1016/s0049-0172(97)80046-7 via openalex

[6] doi:10.1093/rheumatology/35.5.458 via openalex

[7] doi:10.1016/s0092-8674(00)80402-x via openalex