Special Issue "Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases, 2nd Edition"

Papaneophytou C, Felekkis K
International journal of molecular sciences · 2025 · vol. 26(19) · doi:10.3390/ijms26199449 · PMID:41096717 · PMC12524499
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This special issue explores circulating non-coding RNAs as diagnostic and prognostic markers for human diseases, highlighting their role in reflecting cellular and tissue-specific physiological states.

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This editorial introduction for a special issue on circulating non-coding RNAs acknowledges the contributions of authors and reviewers while listing included studies on various diseases such as hearing loss, schizophrenia, gastric cancer, and rheumatoid arthritis. The text explicitly states that no new data was created in this specific manuscript, serving primarily as a preamble to the collection of research articles. One cited paper within the list examines RNA expression profiling in the endometrium of patients with endometriosis, linking the broader theme of biomarkers to reproductive health conditions. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

The dynamic transcriptomic landscape of the human genome, comprising both coding and non-coding RNA (ncRNA) transcripts, serves as a molecular fingerprint of cellular and tissue-specific physiological states [...].
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Ack

We would like to thank all contributing authors and reviewers for their scholarly excellence and commitment to this Special Issue.

Data

No new data was created in this study.

List

Nunez, D.A.; Abgoon, R.; Wijesinghe, P.; Garnis, C. Serum and Plasma miRNA Expression Levels in Sudden Sensorineural Hearing Loss. Int. J. Mol. Sci.   2025 , 26 , 1245. https://doi.org/10.3390/ijms26031245 . Miyano, T.; Hirouchi, M.; Yoshimura, N.; Hattori, K.; Mikkaichi, T.; Kiyosawa, N. Plasma microRNAs Associate Positive, Negative, and Cognitive Symptoms with Inflammation in Schizophrenia. Int. J. Mol. Sci.   2024 , 25 , 13522. https://doi.org/10.3390/ijms252413522 . Piccinno, E.; Schirizzi, A.; Scalavino, V.; De Leonardis, G.; Donghia, R.; Fantasia, A.; Ricci, A.D.; Lotesoriere, C.; Giannelli, G.; Serino, G.; et al. Circulating miR-23b-3p, miR-30e-3p, and miR-205-5p as Novel Predictive Biomarkers for Ramucirumab–Paclitaxel Therapy Outcomes in Advanced Gastric Cancer. Int. J. Mol. Sci.   2024 , 25 , 13498. https://doi.org/10.3390/ijms252413498 . Choi, M.R.; Chang, H.J.; Heo, J.-H.; Yum, S.H.; Jo, E.; Kim, M.; Lee, S.-R. Expression Profiling of Coding and Noncoding RNAs in the Endometrium of Patients with Endometriosis. Int. J. Mol. Sci.   2024 , 25 , 10581. https://doi.org/10.3390/ijms251910581 . Tovar-Cuevas, A.J.; Rosales Gómez, R.C.; Martín-Márquez, B.T.; Peña Dueñas, N.A.; Sandoval-García, F.; Guzmán Ornelas, M.O.; Chávez Tostado, M.; Hernández Corona, D.M.; Corona Meraz, F.-I. Bioinformatic Analysis from a Descriptive Profile of miRNAs in Chronic Migraine. Int. J. Mol. Sci.   2024 , 25 , 10491. https://doi.org/10.3390/ijms251910491 . Mikulski, D.; Kościelny, K.; Dróżdż, I.; Mirocha, G.; Nowicki, M.; Misiewicz, M.; Perdas, E.; Strzałka, P.; Wierzbowska, A.; Fendler, W. Serum Levels of miR-122-5p and miR-125a-5p Predict Hepatotoxicity Occurrence in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation. Int. J. Mol. Sci.   2024 , 25 , 4355. https://doi.org/10.3390/ijms25084355 . Wosniaki, D.K.; Marin, A.M.; Oliveira, R.N.; Koerich, G.M.; Munhoz, E.C.; Farias, J.S.d.H.; Beltrame, M.P.; Zanette, D.L.; Aoki, M.N. The Screening of microRNAs in Chronic Myeloid Leukemia: A Clinical Evaluation. Int. J. Mol. Sci.   2024 , 25 , 3363. https://doi.org/10.3390/ijms25063363 . Patel, R.S.; Krause-Hauch, M.; Kenney, K.; Miles, S.; Nakase-Richardson, R.; Patel, N.A. Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans. Int. J. Mol. Sci.   2024 , 25 , 1473. https://doi.org/10.3390/ijms25031473 . Cieśla, M.; Darmochwal-Kolarz, D.A.; Kwaśniak, K.; Pałka, A.; Kolarz, B. Plasma Circular-RNA 0005567 as a Potential Marker of Disease Activity in Rheumatoid Arthritis. Int. J. Mol. Sci.   2024 , 25 , 417. https://doi.org/10.3390/ijms25010417 . Yan, Q.; Wang, Q. Exploring the Characters of Non-Coding RNAs in Spermatogenesis and Male Infertility. Int. J. Mol. Sci.   2025 , 26 , 1128. https://doi.org/10.3390/ijms26031128 . Seyhan, A.A. Circulating Liquid Biopsy Biomarkers in Glioblastoma: Advances and Challenges. Int. J. Mol. Sci.   2024 , 25 , 7974. https://doi.org/10.3390/ijms25147974 . Felekkis, K.; Papaneophytou, C. The Circulating Biomarkers League: Combining miRNAs with Cell-Free DNAs and Proteins. Int. J. Mol. Sci.   2024 , 25 , 3403. https://doi.org/10.3390/ijms25063403 .

Author

Writing, review, and editing, C.P. and K.F. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

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The authors declare no conflicts of interest.

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MeSH descriptors

Biomarkers Biomarkers Cell-Free Nucleic Acids Cell-Free Nucleic Acids Cell-Free Nucleic Acids RNA, Untranslated RNA, Untranslated RNA, Untranslated Humans Prognosis

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