The effect of follicular fluid selenium concentration on oocyte maturation in women with polycystic ovary syndrome undergoing in vitro fertilization/Intracytoplasmic sperm injection: A cross-sectional study.

Mahsa Poormoosavi S, Behmanesh MA, Varzi HN, Mansouri S, Janati S
International journal of reproductive biomedicine · 2021 · doi:10.18502/ijrm.v19i8.9616 · PMID:34568729 · PMC8458914
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In women with PCOS undergoing IVF, follicular fluid selenium concentrations below 40 μg/dL were associated with a reduced number of mature metaphase II oocytes.

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This cross-sectional study evaluated the impact of follicular fluid selenium concentrations on oocyte quantity and maturation in 78 women with polycystic ovary syndrome undergoing IVF or ICSI. The researchers found that lower selenium levels were significantly associated with reduced counts of mature metaphase II oocytes, while no significant association was observed for total oocyte count or immature stages. Although the study notes prior literature linking elevated reactive oxygen species in follicular fluid to both PCOS and endometriosis, it explicitly excluded patients with endometriosis from its cohort to isolate effects within the PCOS population. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

BackgroundA high level of free radicals and oxidative substances in women with polycystic ovary syndrome (PCOS) can affect the ovaries through oxidative stress. Antioxidants such as selenium, a vital trace element in human health, can improve the prognosis of PCOS by reducing oxidative stress.ObjectiveThis study was performed due to the lack of comprehensive information about selenium concentration in follicular fluid and its effect on the oocyte count and quality in infertile women with PCOS.Materials and methodsIn this cross-sectional study, 78 women with PCOS referred to Umm-al-Banin Infertility Clinic Center, Ganjavian Hospital, Dezful, Iran for in-vitro fertilization from March to November 2019 were enrolled. After ovarian stimulation with the antagonist protocol, the oocytes were retrieved under transvaginal ultrasound in in-vitro fertilization/intracytoplasmic sperm injection cycles, and selenium concentrations were measured in the follicular fluid using an atomic absorption method by spectrophotometer device. Oocyte count and morphology were evaluated using inverted optical microscopy.ResultsThere were no significant differences between follicular fluid selenium concentrations in terms of the total number of oocytes and immature oocytes in the metaphase I and germinal vesicle stages. However, a significantly reduced number of metaphase II oocytes was observed at selenium levels < 40 μg/dL (p = 0.001).ConclusionBased on our results, low levels of follicular selenium concentration in infertile women with PCOS can reduce the quality and potency of oocyte maturation.
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According to the present study, low levels of follicular selenium concentration in infertile women with PCOS are associated with the number, maturity, and quality of oocytes taken from their ovaries. Therefore, it can be concluded that by reducing the FF selenium concentration, the oocyte quantity and maturation are likely to decrease.

Coi Statement

The authors declare they have no conflict of interest.

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