Is prior uterine surgery a risk factor for adenomyosis?

Panganamamula UR, Uma R Panganamamula, Ozgur H Harmanli, Harmanli OH, Isik-Akbay EF, Ebru F Isik-Akbay, Chad A. Grotegut, Grotegut CA, Dandolu V, Vani Dandolu, John P Gaughan, Gaughan JP
Obstetrics and gynecology · 2004 · doi:10.1097/01.AOG.0000143264.59822.73 · PMID:15516398
other OA: closed public-domain-us
Full text JSON View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-08, 2026-08-03 ⓘ

This study found that a history of any prior uterine surgery was significantly associated with an increased risk of adenomyosis in women undergoing hysterectomy for benign conditions.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: The objective of our study was to assess whether prior uterine surgery is a risk factor for adenomyosis. METHODS: Medical records of women who had a hysterectomy for benign conditions between January of 1995 and June of 2002 were reviewed. Women with and without adenomyosis were compared with respect to history of prior uterine surgery, such as cesarean delivery, myomectomy, endometrial ablation, dilation and evacuation, and dilation and curettage. RESULTS: Of 873 completed records available, 412 patients (47.1%) had adenomyosis. Mean age and race distribution were similar between the 2 groups. The group with adenomyosis had significantly higher gravidity (P < .001) and parity (P = .004), but smaller uterine size (P < .001) and uterine weight (P < .001). Univariable analysis for each aforementioned specific surgical procedure did not indicate a significant difference between women with and without adenomyosis. However, history of any prior uterine surgery increased the risk of adenomyosis (48.8% and 41.0%, odds ratio 1.37, 95% confidence interval 1.05-1.79) on univariable analysis. This association remained significant when all of the factors were combined in a multivariable logistic regression model. CONCLUSION: In this study, we found a significantly increased risk of adenomyosis with prior uterine surgery. The absence of significant association with any specific surgical procedure is possibly the result of a smaller number of subjects in each individual group. LEVEL OF EVIDENCE: II-3.
Full text 1,694 characters · extracted from oa-doi-fallback · 4 sections · click to expand

Objective

The objective of our study was to assess whether prior uterine surgery is a risk factor for adenomyosis.

Methods

Medical records of women who had a hysterectomy for benign conditions between January of 1995 and June of 2002 were reviewed. Women with and without adenomyosis were compared with respect to history of prior uterine surgery, such as cesarean delivery, myomectomy, endometrial ablation, dilation and evacuation, and dilation and curettage.

Results

Of 873 completed records available, 412 patients (47.1%) had adenomyosis. Mean age and race distribution were similar between the 2 groups. The group with adenomyosis had significantly higher gravidity (P < .001) and parity (P = .004), but smaller uterine size (P < .001) and uterine weight (P < .001). Univariable analysis for each aforementioned specific surgical procedure did not indicate a significant difference between women with and without adenomyosis. However, history of any prior uterine surgery increased the risk of adenomyosis (48.8% and 41.0%, odds ratio 1.37, 95% confidence interval 1.05–1.79) on univariable analysis. This association remained significant when all of the factors were combined in a multivariable logistic regression model.

Conclusion

In this study, we found a significantly increased risk of adenomyosis with prior uterine surgery. The absence of significant association with any specific surgical procedure is possibly the result of a smaller number of subjects in each individual group. LEVEL OF EVIDENCE: II-3

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Hysterectomy Uterine Diseases Adult Aged Aged, 80 and over Endometriosis Female Humans Logistic Models Middle Aged Multivariate Analysis Retrospective Studies Risk Factors Uterine Diseases Uterine Diseases

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. The paper's references may be in our DB but unresolved to ``paper_id`` (resolution happens at ingest when the cited DOI matches a row we already have). Run the cross-source citation reconcile pass to retry.

Source provenance

europepmc
last seen: 2026-08-08T06:08:32.324769+00:00
pubmed
last seen: 2026-05-13T22:12:26.305326+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine