Effect of French Maritine Pine Bark Extract on Side Effects of Gynecological Hormonal Therapies

Takafumi Kohama
In: Japanese Journal of Complementary and Alternative Medicine · 2010 · vol. 7(1) , pp. 17–24 · doi:10.1625/jcam.7.17 · W2025392853
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

French maritime pine bark extract (pycnogenol) supplementation reduced joint pain and fatigue in Gn-RH analogue therapy and prevented menstrual pain recurrence, while also suppressing edema and weight gain in moderate and low-dose hormone therapy groups.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The study evaluated whether French maritime pine bark extract (pycnogenol) could reduce side effects of gynecological hormonal therapies in patients whose primary complaints were uterine fibroids, dysmenorrhea, or endometriosis. Patients received Gn-RH analogue therapy (G) or medium/low-dose hormonal therapy (M/L) and were assigned to pycnogenol co-therapy during and after treatment (G+P n=8, M+P n=8, L+P n=17) versus control groups without pycnogenol (G n=14, M n=13, L n=23). Continuous pycnogenol co-administration was associated with reduced joint pain and fatigue and a protective effect against recurrence of dysmenorrhea after treatment in the G+P group, and with inhibition of edema and weight gain in the M+P and L+P groups. This paper’s relevance to endometriosis is direct because endometriosis was a primary patient complaint and the authors report improvement of side effects of hormonal therapy in the context of endometriosis.

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Abstract

フランス海岸松樹皮抽出物（ピクノジェノール）のホルモン治療における副作用改善効果を検討するため，子宮筋腫，月経困難症および子宮内膜症を主訴とする患者で，Gn-RH analogue 療法（G 投与群），中等量ホルモン投与療法（M 投与群）および低容量ホルモン投与療法（L 投与群）を行っている患者に対し，ピクノジェノール (P) を治療中および治療後にかけて併用投与した（G+P 投与群；8 名，M+P 投与群；8 名，L+P 投与群；17 名）．同様のホルモン療法を施行し，ピクノジェノールを投与しない患者を対照群（G 投与群＝14 人，M 投与群＝13 人および L 投与群＝23 人）とした．継続的なピクノジェノール併用投与により，G+P 投与群では，関節痛および倦怠感の軽減，治療後の月経困難症の再発予防効果が認められ，M+P 投与群および L+P 投与群では，ピクノジェノール投与による，浮腫ならびに体重増加の抑制効果が認められた．以上より，ピクノジェノールは，従来の月経困難症，子宮内膜症のホルモン療法の副作用の改善，ならびに症状の再発予防の効果を有するものと考えられた．
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原著 婦人科ホルモン療法の副作用に対する，フランス海岸松樹皮抽出物の抑制効果について 2010 年 7 巻 1 号 p. 17-24 詳細 抄録 フランス海岸松樹皮抽出物（ピクノジェノール）のホルモン治療における副作用改善効果を検討するため，子宮筋腫，月経困難症および子宮内膜症を主訴とする患者で，Gn-RH analogue 療法（G 投与群），中等量ホルモン投与療法（M 投与群）および低容量ホルモン投与療法（L 投与群）を行っている患者に対し，ピクノジェノール (P) を治療中および治療後にかけて併用投与した（G+P 投与群；8 名，M+P 投与群；8 名，L+P 投与群；17 名）．同様のホルモン療法を施行し，ピクノジェノールを投与しない患者を対照群（G 投与群＝14 人，M 投与群＝13 人および L 投与群＝23 人）とした．継続的なピクノジェノール併用投与により，G+P 投与群では，関節痛および倦怠感の軽減，治療後の月経困難症の再発予防効果が認められ，M+P 投与群および L+P 投与群では，ピクノジェノール投与による，浮腫ならびに体重増加の抑制効果が認められた．以上より，ピクノジェノールは，従来の月経困難症，子宮内膜症のホルモン療法の副作用の改善，ならびに症状の再発予防の効果を有するものと考えられた． © 2010 日本補完代替医療学会

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