Ulipristalacetate treatment of endometriosis and normal endometrial stromal cells inhibits cell proliferation

The study examined whether ulipristal acetate (UPA), previously shown to block estradiol/progesterone-driven proliferation in normal endometrial cells, would also inhibit proliferation of endometriosis stromal cells. Researchers isolated stromal cells from a deep infiltrating endometriosis lesion and from matched normal endometrium, confirmed steroid hormone receptor gene expression by semi-quantitative real-time PCR, and then measured proliferation after adding UPA (10–100 mM) followed by cell counts at 48 and 72 hours. UPA treatment at 50 µM produced the largest reduction in proliferation at 48 hours, decreasing proliferation more than 2-fold in both normal endometrial cells and endometriosis cells, despite endometriosis stromal cells showing much lower progesterone receptor (PGR) expression than matched normal endometrium. The paper relates to endometriosis by experimentally testing UPA’s antiproliferative effects on stromal cells derived from deep infiltrating endometriosis.

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