Endometriosis and the risk of ovarian cancer: is miR126 the Achille's heel?
This paper discusses the connection between endometriosis and ovarian cancer risk, specifically investigating the potential role of microRNA-126 in this relationship.
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This paper is a brief, conceptual discussion published in 2024 that examines the relationship between endometriosis and the risk of ovarian cancer, framing the question of whether microRNA-126 (miR-126) could be a key mechanistic link. It synthesizes prior findings that report miR-126 dysregulation in endometriosis and describes evidence from ovarian cancer studies where miR-126 is reported to exert antitumor effects via targets such as EGFL7 and pathways related to epithelial-to-mesenchymal transition and ERK/MAPK signaling. The paper’s main limitation is that it does not present new experimental data and instead relies on summarizing and interpreting existing literature. This paper is centrally about endometriosis — it discusses how endometriosis increases ovarian cancer risk and considers miR-126 as a potential mechanistic “Achilles’ heel” connecting the two.
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References (5)
- Endometriosis and risk of ovarian cancer: what do we know? via openalex
- Expression of miR-126 and Crk in endometriosis: miR-126 may affect the progression of endometriosis by regulating Crk expression via openalex
- W2799625384 via openalex
- W2994269641 via openalex
- W3030816795 via openalex
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- europepmc
- last seen: 2026-09-25T06:10:54.854274+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-09-25T06:08:54.883577+00:00
- unpaywall
- last seen: 2026-09-25T06:33:09.130943+00:00