Endometriosis and the risk of ovarian cancer: is miR126 the Achille's heel?

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This paper discusses the connection between endometriosis and ovarian cancer risk, specifically investigating the potential role of microRNA-126 in this relationship.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This paper is a brief, conceptual discussion published in 2024 that examines the relationship between endometriosis and the risk of ovarian cancer, framing the question of whether microRNA-126 (miR-126) could be a key mechanistic link. It synthesizes prior findings that report miR-126 dysregulation in endometriosis and describes evidence from ovarian cancer studies where miR-126 is reported to exert antitumor effects via targets such as EGFL7 and pathways related to epithelial-to-mesenchymal transition and ERK/MAPK signaling. The paper’s main limitation is that it does not present new experimental data and instead relies on summarizing and interpreting existing literature. This paper is centrally about endometriosis — it discusses how endometriosis increases ovarian cancer risk and considers miR-126 as a potential mechanistic “Achilles’ heel” connecting the two.

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References Králíčková M, Laganà AS, Ghezzi F, Vetvicka V (2020) Endometriosis and risk of ovarian cancer: what do we know? Arch Gynecol Obstet 301(1):1–10 Liu S, Gao S, Wang XY, Wang DB (2012) Expression of miR-126 and Crk in endometriosis: miR-126 may affect the progression of endometriosis by regulating Crk expression. Arch Gynecol Obstet 285(4):1065–1072 Zhang Y, Qin X, Jiang J, Zhao W (2020) MicroRNA-126 exerts antitumor functions in ovarian cancer by targeting EGFL7 and affecting epithelial-to-mesenchymal transition and ERK/MAPK signaling pathway. Oncol Lett 20(2):1327–1335 Guo T, Yuan D, Lin M, Zhu D, Xu N, Wang J (2020) Aberrant expression of ADAM9 in ovarian cancer and its clinical significance. J Clin Lab Anal 34(4):e23136 Hua Y, Liang C, Miao C, Wang S, Su S, Shao P, Liu B, Bao M, Zhu J, Xu A, Zhang J, Li J, Wang Z (2018) MicroRNA-126 inhibits proliferation and metastasis in prostate cancer via regulation of ADAM9. Oncol Lett 15(6):9051–9060 Funding The authors have not disclosed any funding. Author information Authors and Affiliations Contributions Author contributions Mormile Raffaella Protocol/project development. Mormile Raffaella Data collection or management. Mormile Raffaella Data analysis. Mormile Raffaella Manuscript writing/editing. Corresponding author Ethics declarations Conflict of interests The author declares no potential conflicts of interest. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions About this article Cite this article Mormile, R. Endometriosis and the risk of ovarian cancer: is miR126 the Achille’s heel?. Arch Gynecol Obstet 310, 1275–1276 (2024). https://doi.org/10.1007/s00404-024-07440-2 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00404-024-07440-2

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endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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