Evaluating the effect of nurses' supportive and educational care on GATA2 gene expression and quality of life in patients with endometriosis

Hai-Yan Zheng, Haiyan Zheng
Cellular and molecular biology (Noisy-le-Grand, France) · 2022 · vol. 68(8) , pp. 145–150 · doi:10.14715/cmb/2022.68.8.26 · PMID:36800818 · W4321441106
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Nurses' supportive and educational care significantly improved quality of life scores and increased GATA2 gene expression in endometriosis patients.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This semi-experimental before-and-after study assessed whether nurses’ supportive and educational care sessions would change quality of life and GATA2 gene expression in 45 endometriosis patients, using quality-of-life questionnaires completed before and after the intervention and real-time PCR on endometrial tissue sampled before and after. After the intervention, average quality of life scores increased from 51.73±13.91 to 60.46±13.80 (P<0.001), with significant improvements specifically in the physical and mental health dimensions. GATA2 expression also rose from 0.35±0.13 to 0.96±0.32 (about threefold; significant at the 5% level). This paper is centrally about endometriosis — it evaluates nurse supportive/educational care effects on quality of life and GATA2 gene expression in endometriosis patients.

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Abstract

Endometriosis is one of the women's aggressive but benign diseases, formed by the presence of endometrial glands and stroma outside the uterine cavity. Various genes, including the GATA2 gene, are involved in the pathogenesis of endometriosis. Since this disease affects patients' quality of life, this study was conducted to investigate the effect of nurses' supportive and educational care on the quality of life of endometriosis patients and its role in GATA2 gene expression. For this purpose, 45 patients with endometriosis participated in this research, a semi-experimental before-and-after study. The instrument used was demographic information and quality of life questionnaires affiliated with Beckman Institute, which were completed in two stages before and after implementing patient training and support sessions. The real-time PCR technique was also used to evaluate the expression level of the GATA2 gene after obtaining endometrial tissue from patients before and after the intervention. Finally, the received information was analyzed using SPSS software and statistical tests. Based on the obtained results, the average quality of life score before the intervention was 51.73±13.91, and after the intervention was 60.46±13.80 (P<0.001). Also, in all four dimensions of quality of life, patients' average scores increased after the intervention compared to before the intervention. Still, this difference was significant only in the two dimensions of physical and mental health (P<0.001). GATA2 gene expression before intervention was 0.35 ± 0.13 among endometriosis patients. After the intervention, its amount reached about three times, i.e., 0.96 ± 0.32, which showed a significant difference between the two groups at the 5% probability level. In general, the results of this research confirmed the positive effect of educational and support programs in improving the quality of life of breast cancer patients. Therefore, it is suggested to design and implement such programs in a broader manner and based on patients' educational and support needs.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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