Pengaruh Hyperbaric Oxygen (HBO) Terhadap EkspresiHypoxia Induced Factor-1 Alpha (HIF-1 Alpha), Vascular Endothelial Growth Factor (VEGF) dan Luas Jaringan Endometriotik Pada Mencit Model Endometriosis
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Abstract
Latar Belakang: Hipoksia pada endometriosis akan meningkatkan ekspresi Hypoxia
\nInducible Factor-1 alpha(HIF-1alpha) selanjutnya meningkatkan ekspresi Vascular
\nEndothelial Growth Factor(VEGF).Hyperbaric Oxygen(HBO) dapat menurunkan
\nekspresi HIF-1alpha karena meningkatkan ubiquitinisasi HIF-1alpha.Inilah peluang bagi
\nHBO agar dapat digunakan sebagai salah satu modalitas pendukung pengobatan
\nendometriosis.
\nTujuan: Menganalisis pengaruh perbedaan dosis HBO 2,4 ATA 3x30 menit perhari
\nselama 10 hari dan 2,4 ATA 90 menit perhari selama 10 hari terhadap ekspresi HIF-1
\nalpha,VEGF dan luas jaringan endometriotik pada mencit model endometriosis.
\nMetode: Desain penelitian ini adalah eksperimental laboratorium dengan rancangan
\npost test only control design yang dilakukan dengan beberapa tahap yaitu pemodelan
\nendometriosis,perlakuan hiperbarik,dan pengumpulan data.Selanjutnya data diuji
\nnormalitas dengan Kolmogorov smirnov dan homogenisitas dengan uji Levene.Bila data
\nberdistribusi normal dan homogen,uji komparasi antar kelompok variabel penelitian
\ndiuji dengan Annova yang dilanjutkan dengan uji post hock LSD.Bila data berdistribusi
\nnormal dan tidak homogen maka perbedaan rerata diuji dengan Brown forshyte yang
\ndilanjutkan dengan uji post hock dengan menggunakan uji Games Howell.Analisis
\nhubungan antara variabel penelitian dilakukan dengan uji regresi linear.
\nHasil: Ekspresi HIF-1alpha dijumpai perbedaan bermakna pada kelompok HBO 2.4
\nATA 3x30 menit/hari.Ekspresi VEGF dijumpai perbedaan bermakna antara kelompok
\nkontrol dengan kelompok HBO 2.4 ATA 3x30 menit/hari.Luas jaringan endometriotik
\ndijumpai perbedaan bermakna pada kelompok HBO 2.4 ATA 3x30 menit/hari.
\nKesimpulan: Terdapat hubungan kuat antara penurunan ekspresi HIF-1alpha dengan
\nekspresi VEGF.Penurunan ekspresi HIF-1alpha merupakan faktor yang memperantarai
\npenurunan luas jaringan endometriosis akibat pemberian HBO 2,4 ATA 3x30 menit
\nperhari selama sepuluh hari.
\nKeywords: Hypoxia, Endometriosis, Hyperbaric Oxygen(HBO), Hypoxia Inducible
\nFactor-1 alpha(HIF-1alpha),Vascular Endothelial Growth Factor (VEGF).
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Keywords
Hypoxia, Endometriosis, Hyperbaric Oxygen (HBO), Hypoxia Inducible
Factor-1
alpha(HIF-1alpha),Vascular Endothelial Growth Factor (VEGF).
ADLN - PERPUSTAKAAN UNIVERSITAS AIRLANGGA
TESIS CUT MUSTIKAPENGARUH HYPERBARIC OXYGEN...
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Abstract
Effect of Hyperbaric Oxygen (HBO) to Expression of Hypoxia Inducible Factor-1
Alpha (HIF-1alpha),Vascular Endothelial Growth Factor (VEGF) and
Endometriotic Tissue Size in Mice ModelEndometriosis
Introduction
Hypoxia in endometriosis will increase the expression of Hypoxia
Inducible Factor-1alpha (HIF-1alpha), which leads to increased expression of Vascular
Endothelial Growth Factor (VEGF).Hyperbaric Oxygen(HBO) can decrease the
expression of HIF-1alpha because will improve ubiquitinisasi HIF-1alpha. This an
opportunity for HBO to be used as one modality that supports the treatment of
endometriosis.
Aims: To analyze the effect of HBO dose difference between dose 2.4 ATA HBO
3x30 minutes per day for 10 days and dose 2.4 ATA 90 minutes per day for 10 days in
expression of HIF - 1 alpha, VEGF and size endometriotic tissue on mice model of
endometriosis.
Methode: This study was an experimental laboratory with post test only control design
conducted with several stages of modeling endometriosis , hyperbaric treatment , and
collection of data. All data tested with Kolmogorov Smirnov analize normality and test
Levene analize homogenous.Data homogeneous with normal distribution, comparison
test between groups of variables were tested with One way Annova followed by post
hock test LSD.Data with normal distribution but not homogeneous, the difference tested
with Brown forshyte followed by post hock test by using test Games Howell.Analisis
relationship among variables was performed by test linear regression.
Results
The expression of HIF-1alpha found significant differences in groups HBO 2.4
ATA 3x30 minutes / day.The expression of VEGF found significant differences between
the control group and 2.4 ATA HBO group 3x30 minutes / day.Size of e ndometriotic
tissue found significant differences in groups HBO 2.4 ATA 3x30 minutes / day.
Conclusion
There is a strong correlation between the decrease in the expression of
HIF- 1alpha with expression VEGF. The decrease of expression HIF 1 lpha is a factor
mediates reduction of size endometriotic tissue that due to the provision of 2.4 ATA
HBO 3x30 minutes per day for ten days.
Keywords
Hypoxia, Endometriosis, Hyperbaric Oxygen (HBO), Hypoxia Inducible
Factor-1
alpha(HIF-1α),Vascular Endothelial Growth Factor(VEGF)
ADLN - PERPUSTAKAAN UNIVERSITAS AIRLANGGA
TESIS CUT MUSTIKAPENGARUH HYPERBARIC OXYGEN...
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