Association of TP53 codon 72 polymorphism in women suffering from endometriosis from Lahore, Pakistan.

Rizwana Hussain, Khaliq S, Saba Khaliq, Syed Mohsin Raza, Raza SM, Shagufta Khaliq, Lone KP, Khalid Pervaiz Lone
JPMA. The Journal of the Pakistan Medical Association · 2018 · vol. 68(2) , pp. 224–230 · PMID:29479097 · W3025391831
article OA: closed CC0 ⤵ 10 in-corpus citations
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This study investigated the TP53 gene codon 72 polymorphism in Pakistani women, finding that the pro/pro genotype increased the odds of developing endometriosis, especially with advanced age.

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Abstract

OBJECTIVE: To investigate TP53 gene codon 72 polymorphism in women with endometriosis and compare it with healthy samples. METHODS: This case-control study was carried out at Jinnah Hospital, Services Hospital and Sheikh Zayed Hospital, Lahore, Pakistan, from 2014 to 2016, and comprised patients with endometriosis and healthy controls. SPSS 21 was used for statistical analysis. RESULTS: Of the 176 participants, 88(50%) were healthy controls and 88(50%) were endometriosis patients. The observed genotype frequencies for controls and patients were 14(15.9%) and 31(35.3%) for proline/proline, 46(52.3%) and 35(39.8%) for proline/arginine, and 28(31.8%) and 22(25%) for arginine/arginine, respectively. The association of different genotypes was not significant in patients with moderate-to-severe endometriosis (p=0.574). The presence of pro/pro genotype enhanced the chances/odds of getting the disease (p<0.05). However, the risk further increased with the advancement of age, particularly in the 27-46 age group (p<0.05). CONCLUSIONS: In Pakistani women the association of TP53 gene codon 72 arginine/proline polymorphism was present..

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Tumor Suppressor Protein p53 Adolescent Adult Endometriosis Female Genetic Predisposition to Disease Genotype Humans Middle Aged Pakistan Polymorphism, Genetic Tumor Suppressor Protein p53 Young Adult

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