Endothelin-1 and big endothelin-1 increase in human endometrium during menstruation

H. Ohbuchi, Kimihiro Nagai, Masatoshi Yamaguchi, Tsuyomu Ikenoue, Norimasa Mori, Katzuo Kitamura, S. Araki, Kiyotaka Toshimori
In: American Journal of Obstetrics and Gynecology · 1995 · vol. 173(5) , pp. 1483–1490 · doi:10.1016/0002-9378(95)90637-1 · PMID:7503189 · W2002341382
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This study found that endothelin-1 and big endothelin-1 levels increase in the human endometrium during menstruation.

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Abstract

ObjectivesAlthough the physiologic and pathologic roles of endothelin-1 in reproduction have been investigated, little is known about human uterine tissue levels. We studied the levels of immunoreactive endothelin-1 and immunoreactive big endothelin-1 in human endometrium and myometrium during each menstrual phase.Study designMaterials were obtained at hysterectomy (endometrium, n = 33; myometrium, n = 27). We measured immunoreactive endothelin-1 and immunoreactive big endothelin-1 by radioimmunoassay and performed an immunohistochemical study of the tissue. Data were analyzed by the Mann-Whitney U test.ResultsWe detected larger amounts of immunoreactive endothelin-1 and immunoreactive big endothelin-1 in the endometrium than in the myometrium throughout the menstrual, proliferative, and secretory phases. Endometrial immunoreactive endothelin-1 and immunoreactive endothelin-1 were significantly increased in the menstrual phase (endothelin-1 68.8 +/- 23.3 pg/mg protein, n = 5, p < 0.005; big endothelin-1 45.2 +/- 5.7 pg/mg protein, n = 5, p < 0.003) compared with the other phases (endothelin-1 30.7 +/- 9.5 and 30.5 +/- 14.0 pg/mg protein; big endothelin-1 19.9 +/- 6.7 and 24.1 +/- 7.4 pg/mg protein). Immunohistochemistry demonstrated that the endometrial stromal cells were positive for antiendothelin monoclonal antibody only in the premenstrual and menstrual phases.ConclusionLevels of immunoreactive endothelin-1 and immunoreactive big endothelin-1 are different in each type of uterine tissue and in each phase of the menstrual cycle. These changes may indicate some role of endothelin-1 in menstruation.

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