Editorial: Immunocellular mechanisms and endocrine organs
This editorial reviews articles exploring innate immune mechanisms in endometriosis, highlighting the roles of macrophages, HMGB-1, and specific gene signatures in disease pathogenesis and potential biomarker identification.
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This editorial introduces a research topic exploring the complex crosstalk between innate immune cells and endocrine organs, highlighting their roles in maintaining homeostasis and contributing to chronic diseases. The text summarizes several studies, including one that identifies five genes related to macrophage activation as potential diagnostic biomarkers for endometriosis through bioinformatics analysis of genomic databases. It also reviews other investigations into inflammatory markers like HMGB-1 in trauma, pentraxin 3 in thyroid disorders, and natural killer cell dynamics in Graves' disease and pancreatitis. Relevance to endometriosis: listed as one condition among others (such as diabetes and thyroid disorders) where innate immunity plays a pathogenic role, with specific mention of gene expression profiles associated with ectopic endometrial tissue.
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- europepmc
- last seen: 2026-09-20T09:27:46.357103+00:00
- pubmed
- last seen: 2026-09-23T06:13:40.190635+00:00
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