Editorial: Immunocellular mechanisms and endocrine organs

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This editorial reviews articles exploring innate immune mechanisms in endometriosis, highlighting the roles of macrophages, HMGB-1, and specific gene signatures in disease pathogenesis and potential biomarker identification.

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This editorial introduces a research topic exploring the complex crosstalk between innate immune cells and endocrine organs, highlighting their roles in maintaining homeostasis and contributing to chronic diseases. The text summarizes several studies, including one that identifies five genes related to macrophage activation as potential diagnostic biomarkers for endometriosis through bioinformatics analysis of genomic databases. It also reviews other investigations into inflammatory markers like HMGB-1 in trauma, pentraxin 3 in thyroid disorders, and natural killer cell dynamics in Graves' disease and pancreatitis. Relevance to endometriosis: listed as one condition among others (such as diabetes and thyroid disorders) where innate immunity plays a pathogenic role, with specific mention of gene expression profiles associated with ectopic endometrial tissue.

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References

1 PaludanSRPradeuTMastersSLMogensenTH. Constitutive immune mechanisms: mediators of host defence and immune regulation. Nat Rev Immunol (2021) 21:137–50. doi: 10.1038/s41577-020-0391-5 2 DonnezJCacciottolaL. Endometriosis: an inflammatory disease that requires new therapeutic options. Int J Mol Sci (2022) 23(3):1518. doi: 10.3390/ijms23031518 3 Meng-HsingWKuei-YangHShaw-JenqT. Endometriosis and possible inflammation markers. Gynecol Min Invasiv Ther (2015) 4:61–7. doi: 10.1016/j.gmit.2015.05.001 4 TavernaSTonacciAFerraroMCammarataGCuttittaGBucchieriSet al. High mobility group box 1: biological functions and relevance in oxidative stress related chronic diseases. Cells (2022) 11(5):849. doi: 10.3390/cells11050849 5 ZittiBBrycesonYT. Natural killer cells in inflammation and autoimmunity. Cytokine Growth Factor Rev (2018) 42:37–46. doi: 10.1016/j.cytogfr.2018.08.001 6 GalloDPiantanidaEGallazziMBartalenaLTandaMLBrunoAet al. Immunological drivers in graves' disease: NK cells as a master switcher. Front Endocrinol (Lausanne) (2020) 11:406. doi: 10.3389/fendo.2020.00406 7 GalloDMortaraLVeronesiGCattaneoSAMGenoniAGallazziM. Add-on effect of selenium and vitamin d combined supplementation in early control of graves' disease hyperthyroidism during methimazole treatment. Front Endocrinol (Lausanne) (2022) 13:886451. doi: 10.3389/fendo.2022.886451 8 WynnTAChawlaAPollardJW. Macrophage biology in development, homeostasis and disease. Nature (2013) 496(7446):445–55. doi: 10.1038/nature12034 9 CalderonBCarreroJAFerrisSTSojkaDKMooreLEpelmanSet al. The pancreas anatomy conditions the origin and properties of resident macrophages. J Exp Med (2015) 212(10):1497–512. doi: 10.1084/jem.20150496 Summary

Keywords

niche innate immune cells, cytokines in endocrine disorders, drivers of endocrine tissue remodelling, thyroid, aging, macrophages, natural killer cells, endometriosis Citation Gallo D and Ali Y (2023) Editorial: Immunocellular mechanisms and endocrine organs. Front. Endocrinol. 14:1214230. doi: 10.3389/fendo.2023.1214230 Received 29 April 2023 Accepted 04 May 2023 Published 16 May 2023 Volume 14 - 2023 Edited and reviewed by Ralf Jockers, Université Paris Cité, France Updates Copyright © 2023 Gallo and Ali. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: Daniela Gallo, [email protected]; Yusuf Ali, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines Cytokines

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