The Impact of Long Term Estrogen Support After Hysterectomy

Benjamin F. Byrd, John C. Burch, William K. Vaughn
In: Annals of Surgery · 1977 · vol. 185(5) , pp. 574–580 · doi:10.1097/00000658-197705000-00010 · PMID:193450 · W2063675768
article OA: green CC0 ⤵ 1 in-corpus citation
🔓 Open OA copy Full text JSON View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-14 ⓘ

Long-term estrogen support in 1016 post-hysterectomy women over 14,318 patient-years showed decreased all-cause mortality, primarily from reduced heart attacks and cancers, alongside improved osteoporosis but an increase in breast cancer incidence.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-14 · read from full text ⓘ

The paper followed 1016 women who received long-term estrogen support after hysterectomy (mostly conjugated estrogen 1.5 mg/day), totaling 14,318 patient-years. It reported a marked decrease in all-cause mortality compared with expected numbers, attributing this primarily to fewer deaths from heart attack and from cancer, while causes thought unrelated to hormonal therapy matched expected mortality. The authors also found improved clinical evidence of osteoporosis and noted an increase in breast cancer incidence compared with expected, although breast-cancer mortality was lower than anticipated. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

1016 Women were placed on estrogen support following hysterectomy and have been followed for a total of 14,318 patient/years. Support was principally conjugated estrogen with the customary dose 1.5 mg/day. The follow-up studies in this group of women shows a marked drop in deaths from all causes over those which might have been expected. This improvement in mortality is principally the result of diminished number of deaths from heart attack and from cancer. Those causes of death which would not be expected to be related to hormonal therapy show the anticipated number of mortalities. There is also a marked improvement in the clinical evidence of osteoporosis. In this group there is an increase in the number of breast cancers over those which might have been expected, but there is a lower mortality from breast cancer than the anticipated mortality. The general impact of long-term estrogen therapy following hysterectomy is favorable over those figures for the expected incidence of cancer and heart disease.
Full text 1,438 characters · extracted from oa-html · click to expand
Abstract 1016 Women were placed on estrogen support following hysterectomy and have been followed for a total of 14,318 patient/years. Support was principally conjugated estrogen with the customary dose 1.5 mg/day. The follow-up studies in this group of women shows a marked drop in deaths from all causes over those which might have been expected. This improvement in mortality is principally the result of diminished number of deaths from heart attack and from cancer. Those causes of death which would not be expected to be related to hormonal therapy show the anticipated number of mortalities. There is also a marked improvement in the clinical evidence of osteoporosis. In this group there is an increase in the number of breast cancers over those which might have been expected, but there is a lower mortality from breast cancer than the anticipated mortality. The general impact of long-term estrogen therapy following hysterectomy is favorable over those figures for the expected incidence of cancer and heart disease. Full text PDFSelected References These references are in PubMed. This may not be the complete list of references from this article. - KNOWELDEN J., BUHR A. J., DUNBAR O. INCIDENCE OF FRACTURES IN PERSONS OVER 35 YEARS OF AGE. A REPORT TO THE M.R.C. WORKING PARTY ON FRACTURES IN THE ELDERLY. Br J Prev Soc Med. 1964 Jul;18:130–141. doi: 10.1136/jech.18.3.130. [DOI] [PMC free article] [PubMed] [Google Scholar]

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cited by (1)

References (1)

Cited by (1)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK