Chemically Assisted Dissection of Tissues in Laparoscopic Excision of Endometriotic Cysts

Benassi L, Luigi Benassi, L Benassi, G. Benassi, Gianluca Benassi, Benassi G, Kaihura CT, Christine Tita Kaihura, C. Kaihura, Marconi L, Lorenza Marconi, Luisa Ricci, Ricci L, Eugenio Vadora, Vadora E, E Vadora
The Journal of the American Association of Gynecologic Laparoscopists · 2003 · vol. 10(2) , pp. 205–209 · doi:10.1016/s1074-3804(05)60300-3 · PMID:12732773 · W2073811681
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This study describes a method for chemically assisted dissection of tissues during laparoscopic excision of endometriotic cysts, aiming to improve surgical technique.

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Abstract

Study objectiveTo evaluate the capacity of chemical dissection of tissues using a mucolytic substance, Mesna, in improving laparoscopic excision of endometriotic cysts.DesignRandomized, double-blind, controlled trial (Canadian Task Force classification I).SettingUniversity-affiliated training hospital.PatientsForty-four women with symptomatic ovarian endometriotic cysts. Intervention. Laparoscopic excision of endometriotic cysts in 22 women with the aid of Mesna solution and in 22 with the aid of saline solution.Measurements and main resultsIn comparison with saline solution, Mesna as a chemical dissector resulted in significant reductions in operating time, in difficulty encountered by the surgeon to enucleate the cysts, and in less bleeding. No differences were found in length of hospital stay, costs of surgeries, analgesic requirement, and fever. Postoperatively, patients treated with Mesna achieved more pregnancies than those treated with saline.ConclusionChemical dissection of tissues with Mesna proved to be a safe and suitable support in laparoscopic surgery for ovarian endometriotic cysts.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Laparoscopy Mesna Ovarian Cysts Ovarian Diseases Adult Combined Modality Therapy Dissection Double-Blind Method Endometriosis Endometriosis Endometriosis Female Follow-Up Studies Humans Laparoscopy Mesna Ovarian Cysts Ovarian Cysts Ovarian Cysts

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