Endometriosis with Perineural Involvement

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AI-generated summary by claude@2026-06, 2026-06-08

This report describes a case of endometriosis with nonneoplastic endometrial glands found within the perineural space of the uterosacral ligament.

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Abstract

A case of endometriosis involving the right uterosacral ligament in which nonneoplastic endometrial glands were present in the perineural space is reported. In the past, epithelial invasion of the perineural space was considered evidence of the presence of malignant disease. Rodin and colleagues,2 however, concluded that the perineural space is not a lymphatic space and that involvement may represent extension into the tissue plane of least resistance. Perineural invasion has been reported in benign conditions of the breast, including chronic cystic disease and sclerosing adenosis. It is important that involvement of the perineural space in endometriosis not be interpreted as evidence of malignancy. We believe that involvement of the perineural space in other nonmalignant conditions will be described in the future.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Diagnosis, Differential Endometrial Hyperplasia Endometrial Hyperplasia Endometriosis Endometriosis Endometrium Endometrium Female Humans Hysterectomy Laparotomy Middle Aged Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (19)

Source provenance

europepmc
last seen: 2026-06-11T06:19:48.454388+00:00
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License: CC0 · commercial use OK