Correlation between replicative senescence of endometrial gland epithelial cells in shedding and non-shedding endometria and endometriosis cyst during menstruation

Cong-Xiang Yu, Yu CX, Jing-Hui Song, Jinghui Song, Song JH, Li YF, Yue-Fei Li, Yuefei Li, Ya Tuo, Tuo Y, Zheng JJ, Jingjing Zheng, Jing-Jing Zheng, Miao RJ, Rui-Jing Miao, Wang F, Fei Wang, Jing Liu, Liu J, Lei Liang, Liang L
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2018 · vol. 34(11) , pp. 981–986 · doi:10.1080/09513590.2018.1480709 · PMID:30044170 · W2884770885
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Musashi-1 and β-catenin were highly expressed and correlated in shedding and non-shedding endometria, with altered epithelial cell ultrastructure, suggesting a link to endometriosis cyst formation.

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Abstract

To investigate correlation between abnormal replicative senescence of endometrial gland epithelial cells (EGECs) in shedding and non-shedding endometria and endometriosis cyst during menstruation. Musashi-1 expression, β-catenin expression, and EGECs ultrastructure in shedding and non-shedding endometrium when menstruation were observed through real-time PCR and transmission electron microscopy technologies. (1) Musashi-1 and β-catenin exhibited a high expression in shedding and non-shedding endometria in experimental group, showing a positive correlation between each other; and were significantly higher than that in control group. However; there was no correlation between these two in control group. (2) Transmission electron microscopy results: In experimental group, organelles in EGECs in shedding endometrium obtained were abundant on the first day of menstruation, nuclei were irregular, double nucleoli could be observed, and chromatin was rich. Furthermore, morphology of EGECs in non-shedding endometrium was irregular, organelles were abundant, basement membrane was irregular with abnormal curvature, and a large amount of collagenic fibers were found in intercellular spaces. On the fifth day of menstruation, the cilia and microvilli on secretory cells in endometrium increased and prolongated, and organelles became extremely rich. EGECs have potentials of division, proliferation, invasion and migration; and is associated with formation of endometriosis cysts.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Adult Adult Case-Control Studies Case-Control Studies Cellular Senescence Cellular Senescence Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Humans Humans Menstruation Menstruation

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