Ovarian Remnant Syndrome, a Reappraisal: The Usefulness of Clomiphene Citrate in Stimulating and Pelvic Ultrasound in Locating Remnant Ovarian Tissue

Paul F. Kaminski, Jon W. Meilstrup, D. Paul Shackelford, Joel I. Sorosky, Gary A. Thieme
In: Journal of Gynecologic Surgery · 1995 · vol. 11(1) , pp. 33–39 · doi:10.1089/gyn.1995.11.33 · W2043490774
article OA: closed CC0 ⤵ 6 in-corpus citations
View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Clomiphene citrate stimulation followed by pelvic ultrasound identified remnant ovarian tissue in four of six women with post-oophorectomy pain, aiding in diagnosis and surgical planning.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Our objective was to review the criteria for diagnosis of ovarian remnant syndrome and evaluate the role of pelvic sonography following stimulation of remnant ovarian tissue with clomiphene citrate. We evaluated 6 women with a history of previous bilateral oophorectomy with continued pelvic pain. All had premenopausal follicle-stimulation hormone and luteinizing hormone levels. Following a baseline pelvic ultrasound, we arbitrarily administered clomiphene citrate 100 mg daily for 10 days. We then obtained a pelvic sonogram to document the presence and location of presumed remnant ovarian tissue. In 4 women, cystic structures consistent with ovarian follicles were present. Surgery was successful in removing the remnant ovarian tissue in 3 of 4 women. Two women chose medical therapy consisting of ovarian suppression. One of these women had cyclic vaginal bleeding from endogenous hormonal stimulation of vaginal endometriosis as her major complaint. Two of the 3 women without histologic documentation of ovarian tissue had on pelvic sonography the presence of sonographic lucencies consistent with ovarian follicular development. Clomiphene citrate and pelvic sonography are useful in identifying the presence and location of remnant ovarian tissue in some patients. Additionally, the presence of cyclic vaginal bleeding following intended bilateral oophorectomy argues for the presence of residual ovarian tissue in the absence of hormone replacement therapy. (J GYNECOL SURG 11:33, 1995)

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (18)

Cited by (6)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK