Nucleolar organiser regions in normal, hyperplastic, and neoplastic endometria

Wilkinson N, N Wilkinson, Buckley Ch, C. H. Buckley, L Chawner, Chawner L, H. Fox, Fox H
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 1990 · doi:10.1097/00004347-199001000-00005 · PMID:2294063
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This study found that higher AgNOR counts in endometrial tissue correlate with proliferative activity, with counts over 9 in atypical lesions strongly suggesting invasive neoplasia.

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This study investigated nucleolar organizer regions (NORs) as markers of cellular proliferation by analyzing silver-stained AgNOR counts in normal, hyperplastic, and neoplastic endometrial tissues. The researchers found that the highest AgNOR counts occurred in normal proliferative endometrium and well-differentiated endometrioid adenocarcinomas with myometrial invasion. They further determined that a mean AgNOR count exceeding nine in curettage samples from atypical proliferative lesions is highly indicative of invasive neoplasm. Relevance to endometriosis: This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Nucleolar organiser regions (NORs) can be visualised by a silver stain that shows NOR-associated proteins as black intranuclear dots (AgNORs). NORs are loops of DNA that transcribe to ribosomal RNA, and the number of AgNORs is thought to reflect cellular proliferative activity. A study of AgNOR counts in normal, hyperplastic, and neoplastic endometria is reported. The highest AgNOR counts were found in normal proliferative endometrium and in well-differentiated endometrioid adenocarcinomas that were invading the myometrium. A mean AgNOR count of greater than 9 in curettage material from an atypical proliferative lesion of the endometrium is highly suggestive of an invasive neoplasm.
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Original Contributions: PDF Only Nucleolar Organiser Regions in Normal, Hyperplastic, and Neoplastic Endometria - Nafisa Wilkinson - C Hilary Buckley - Linda Chawner - Harold Fox International Journal of Gynecological Pathology 9(1):p 55-59, January 1990. Summary: Nucleolar organiser regions (NORs) can be visualised by a silver stain that shows NOR-associated proteins as black intranuclear dots (AgNORs). NORs are loops of DNA that transcribe to ribosomal RNA, and the number of AgNORs is thought to reflect cellular proliferative activity. A study of AgNOR counts in normal, hyperplastic, and neoplastic endometria is reported. The highest AgNOR counts were found in normal proliferative endometrium and in well-differentiated endometrioid adenocarcinomas that were invading the myometrium. A mean AgNOR count of >9 in curettage material from an atypical proliferative lesion of the endometrium is highly suggestive of an invasive neoplasm. Copyright ©1990International Society of Gynecological Pathologists

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Endometrial Hyperplasia Endometriosis Endometrium Nucleolus Organizer Region Uterine Neoplasms Adenocarcinoma Adenocarcinoma Endometrial Hyperplasia Endometriosis Endometrium Female Humans Nucleolus Organizer Region Uterine Neoplasms Uterine Neoplasms

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pubmed
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