{"paper_id":"3a0d146e-09a9-4641-a179-032bb3811b28","body_text":"Original Contributions: PDF Only\nNucleolar Organiser Regions in Normal, Hyperplastic, and Neoplastic Endometria\n- Nafisa Wilkinson\n- C Hilary Buckley\n- Linda Chawner\n- Harold Fox\nInternational Journal of Gynecological Pathology 9(1):p 55-59, January 1990.\nSummary:\nNucleolar organiser regions (NORs) can be visualised by a silver stain that shows NOR-associated proteins as black intranuclear dots (AgNORs). NORs are loops of DNA that transcribe to ribosomal RNA, and the number of AgNORs is thought to reflect cellular proliferative activity. A study of AgNOR counts in normal, hyperplastic, and neoplastic endometria is reported. The highest AgNOR counts were found in normal proliferative endometrium and in well-differentiated endometrioid adenocarcinomas that were invading the myometrium. A mean AgNOR count of >9 in curettage material from an atypical proliferative lesion of the endometrium is highly suggestive of an invasive neoplasm.\nCopyright ©1990International Society of Gynecological Pathologists","source_license":"public-domain-us","license_restricted":false}