TRH test before, during, and after long-term danazol treatment in patients with endometriosis

Dimitrios Panidis, D K Panidis, I M Matalliotakis, Ioannis Matalliotakis, M D Vayonas, G D Vlassis, G. Vlassis, Andreas P. Kalogeropoulos, A P Kalogeropoulos
Human Reproduction · 1989 · vol. 4(8) , pp. 903–905 · doi:10.1093/oxfordjournals.humrep.a137008 · PMID:2515206 · W2249246839
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Abstract

Ten patients suffering from endometriosis were treated with danazol at a dose of 200 mg three times daily for 6 months. A thyrotropin-releasing hormone (TRH) test was carried out in the follicular phase before treatment, at the sixth month of treatment and after reappearance of the second menses. There was no statistically significant change in the basal level of serum thyroid stimulating hormone (TSH) during danazol treatment. On the contrary, the response of serum TSH in the TRH test was significantly higher during danazol treatment than before or after treatment. Our results support the view that danazol may reduce the secretion of hypothalamic TRH.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Danazol Endometriosis Pregnadienes Thyrotropin-Releasing Hormone Adult Danazol Endometriosis Endometriosis Female Follicular Phase Humans Pregnadienes Thyrotropin Thyrotropin

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