Impact of semen characteristics on the success of intrauterine insemination.

Patients: To evaluate the influence of sperm characteristics on the outcome of infertility treatment using intrauterine insemination (IUI).

Retrospective study of 431 infertility couples who underwent 1007 IUI treatment cycles from June 1999 to October 2002. Sperm parameters before and after preparation for IUI were evaluated and correlated with pregnancy outcome.

Clinical pregnancy occurred in 12% of cycles and 28% of patients. Initial sperm motility and processed forward progression were independently associated with pregnancy after IUI. The mean number of cycles per patient was 4.3. Although pregnancy rate per cycle did not differ from cycle to cycle, the cumulative pregnancy rate approached plateau after five cycles.

Sperm motility is an independent factor influencing IUI-related pregnancy. A forward progression score of 3 to 4 in a processed specimen is necessary for IUI success. The number of IUI attempts per patient should be individualized depending upon the needs of patients. Similar content being viewed by others

Keck C, Gerber-Schafer C, Breckwoldt M: Intrauterine insemination as first line treatment of unexplained and male factor infertility. Eur J Obstet Gynecol Reprod Biol 1998;79:193-197 Goverde AJ, McDonnell J, Vermeiden JPW, Schats R, Rutten FFH, Schoemaker J: Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: A randomised trial and cost-effectiveness analysis. The Lancet 2000;355:13-18 VanVoorhis BJ, Barnett M, Sparks AET, Syrop CH, Rosenthal G, Dawson J: Effect of the total motile sperm count on the efficacy and cost-effectiveness of intrauterine insemination and in vitro fertilization. 2001;75:661-668 Dickey RP, Pyrzak R, Lu PY, Taylor SN, Rye PH: Comparison of the sperm quality necessary for successful intrauterine insemination with World Health Organization threshold values for normal sperm. Fertil Steril 1999;71:684-689 Dickey RP, Taylor SN, Lu PY, Sartor BM, Rye PH, Pyrzak R: Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate-intrauterine insemination. Fertil Steril 2002;78:1088-1095 Miller DC, Hollenbeck BK, Smith GD, Randolph JH,Christman GM, Smith YR, Lebovic DI, Ohl DA: Processed total motile sperm count correlates with pregnancy outcome after intrauterine insemination. Urology 2002;60:497-501 World Health Organization (WHO): Laboratory Manual for the Examination of Human Semen and Sperm–Cervical Mucus Interaction, 4th edn. Cambridge, UK, Cambridge University Press, 1999, pp 4-33 Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Veeck LL, Morshedi M, Brugo S: New method of evaluating sperm morphology with predictive value for human in vitro fertilization. Urology 1987;30:248-251 Guzick DS, Carson SA, Coutifaris C, Overstreet JW,Factor-Litvak P, Steinkampf MP, Hill JA, Mastroianni L, Buster JE, Nakajima ST, Vogel DL, Canfield RE: Efficacy of superovulation and intrauterine insemination in the treatment of infertility. N Engl J Med 1999;340:177-183 Hendin BN, Falcone T, Hallak J, Nelson DR, Vemullapalli S, Goldberg J, Thomas AJ, Jr, Agarwal A: The effect of patient and semen characteristics on live birth rates following intrauterine insemination: A retrospective study. J Assist Reprod Genet 2000;17:245-252 Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK,Nakajima ST, Coutifaris C, Carson SA, Cisneros P, Steinkampf MP, Hill JA, Xu D, Vogel DL: Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 2001;345:1388-1393 Francavilla F, Romano R, Santucci R, Poccia G: Effect of sperm morphology and motile sperm count on outcome of intrauterine insemination in oligozoospermia and/or asthenozoospermia. Fertil Steril 1990;53:892-897 Terada Y, Fukaya T, Haraya H, Yajima A: Sperm motility characteristics and pregnancy outcome of artificial insemination with husband's semen for male infertility. Tohoku J Exp Med 1995;177:337-341 Milingos S, Comhaire FH, Liapi A, Aravantinos D: The value of semen characteristics and tests of sperm function in selecting couples for intra-uterine insemination. Eur J Obstet Gynecol Reprod Biol 1996;64:115-118 Huang HY, Lee CL, Lai YM, Chang MY, Wang HS, Chang SY, Soong YK: The impact of the total motile sperm count on the success of intrauterine insemination with husband's spermatozoa. J Assist Reprod Genet 1996;13:56-63 Campana A, Sakkas D, Stalberg A, Bianchi PG, Comte I, Pache T, Walker D: Intrauterine insemination: Evaluation of the results according to the woman's age, sperm quality, total sperm count per insemination and life table analysis. Hum Reprod 1996;11:732-736 Author information Authors and Affiliations Rights and permissions About this article Cite this article Zhao, Y., Vlahos, N., Wyncott, D. et al. Impact of Semen Characteristics on the Success of Intrauterine Insemination. J Assist Reprod Genet 21, 143–148 (2004). https://doi.org/10.1023/B:JARG.0000031246.76666.f6 Issue date: DOI: https://doi.org/10.1023/B:JARG.0000031246.76666.f6