Perbandingan Skala Nyeri Pasien Kista Endometriosis Dan Adenomiosis Sebelum Operasi, Setelah Operasi Dan Setelah Pemberian GNRH Analog

In: JOURNAL OBGIN EMAS · 2020 · vol. 4(1) , pp. 63–76 · doi:10.25077/aoj.4.1.63-76.2020 · W4254626218
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This study compared endometriosis pain scales before surgery, after surgery, and after GnRH analogue administration, finding a significant reduction in pain post-surgery.

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This observational analytic retrospective cohort study examined pain scores in 35 women diagnosed by ultrasonography and anatomical pathology with endometriosis cysts and/or adenomyosis, assessing pain during menstruation before surgery, during the first menstruation after surgery, and during the first menstruation after three GnRH analog injections. Pain was measured using the Wong-Baker Faces Pain Rating Scale, and changes were analyzed with SPSS using Wilcoxon tests, with significance set at p<0.05. The authors report a significant reduction in pain after surgery compared with before surgery (p=0.0001). This paper is centrally about endometriosis and adenomyosis — it compares pain scale changes before surgery, after surgery, and after GnRH analog administration in patients with endometriosis cysts and adenomyosis.

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Abstract

Background : Endometriosis is the growth of the epithelium and endometrial glands outside the uterine cavity. In endometriosis there is a process of neurogenesis and angiogenesis. The degree of endometriosis pain depends on the depth of endometrial implant infiltration in nerve fibers and / or neurogenesis. Operative action and postoperative hormone therapy are the main choices for preventing recurrence and reducing pain complaints. Purpose : to determine the comparison of pain scales of patients with endometriosis before surgery, after surgery and after administration of GnRH analogues. Method : This study was an observational analytic with a retrospective cohort design in the Obstetrics and Gynecology Clinic of RSUP Dr. M. Djamil Padang in June 2017 to January 2018. The sample size were of 35 people with inclusion and exclusion criteria. The inclusion criteria were the diagnosis of endometriosis (endometriosis cysts and adenomyosis) from ultrasonography and anatomical pathology, had surgery and received analogue GnRH injection three times. Exclusion criteria were not proven endometriosis, hysterectomy surgery, using analgesics and not following analogue GnRH injection procedures. The pain scale is assessed by the Wong-Baker Faces Pain Rating Scale. The pain scale is assessed during menstruation before surgery, first menstruation after surgery and first menstruation after three analogues of GnRH injections. Data analysis using SPSS version 22, where univariate analysis is used to see the characteristics of respondents and bivariate analysis using Wilcoxon Test. Statistical test results were significant if p <0.05. Result : Based on the Wilcoxon statistical test results obtained p value = 0.0001 (p value <0.05) which can be concluded that there is a significant reduction in the pain of endometriosis of patients after surgery compared to before surgery. Conclusion : There was a significant decrease in pain in endometriosis patients before surgery . Keywords: Endometriosis, Adenomyosis, Pain Scale, GnRH anaologist
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Background

Endometriosis is the growth of the epithelium and endometrial glands outside the uterine cavity. In endometriosis there is a process of neurogenesis and angiogenesis. The degree of endometriosis pain depends on the depth of endometrial implant infiltration in nerve fibers and / or neurogenesis. Operative action and postoperative hormone therapy are the main choices for preventing recurrence and reducing pain complaints. Purpose: to determine the comparison of pain scales of patients with endometriosis before surgery, after surgery and after administration of GnRH analogues.

Method

This study was an observational analytic with a retrospective cohort design in the Obstetrics and Gynecology Clinic of RSUP Dr. M. Djamil Padang in June 2017 to January 2018. The sample size were of 35 people with inclusion and exclusion criteria. The inclusion criteria were the diagnosis of endometriosis (endometriosis cysts and adenomyosis) from ultrasonography and anatomical pathology, had surgery and received analogue GnRH injection three times. Exclusion criteria were not proven endometriosis, hysterectomy surgery, using analgesics and not following analogue GnRH injection procedures. The pain scale is assessed by the Wong-Baker Faces Pain Rating Scale. The pain scale is assessed during menstruation before surgery, first menstruation after surgery and first menstruation after three analogues of GnRH injections. Data analysis using SPSS version 22, where univariate analysis is used to see the characteristics of respondents and bivariate analysis using Wilcoxon Test. Statistical test results were significant if p <0.05.

Result

Based on the Wilcoxon statistical test results obtained p value = 0.0001 (p value <0.05) which can be concluded that there is a significant reduction in the pain of endometriosis of patients after surgery compared to before surgery.

Conclusion

There was a significant decrease in pain in endometriosis patients before surgery.

Keywords

Endometriosis, Adenomyosis, Pain Scale, GnRH anaologistReferences Farguhar C. Endometriosis. BMJ : British Medical Journal. 2007;334: 249-53. Rolf, Treede D. The International Association for the Study of Pain definition of pain: as valid in 2018 as in 1979, but in need of regularly updated footnotes. Department of Neurophysiology, Center for Biomedicine and Medical Technology Mannheim, Heidelberg University, Mannheim, Germany.2018;1-3 Vercellini P. Fedele L. Pietropaolo G. Consonni D. Crosignani P. Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients. Human Reproduction.2007;266-71. Jones K. Sutton C. Laparoscopic management of ovarian endometriomas: a critical review of current practice. Curr Opin Obstet Gynecol.2000 ;12:309-15. Jacobson T. Duffy J. Barlow D. Koninckx P. Garry R. Laparoscopic surgery for pelvic pain associated with endometriosis. Cochrane Database Syst Re. 2009;4:1-21 Bloski T. Pierson R. Endometriosis and Chronic Pelvic Pain: Unraveling the Mystery Behind this Complex Condition: Nursing for women's health. 2008;12:382-95. Yap C. Furness S. Farquhar C. Pre and post operative medical therapy for endometriosis surgery. Cochrane Database Syst Rev.2004;3:1-56 Busacca M. Marana R. Caruana P. Candiani M. Muzii L. Calia C. Bianchi S. Recurrence of ovarian endometrioma after laparoscopic excision. Am J Obstet Gynecol .1999;180(3):519-23 Porpora MG. Pallante D. Ferro A. Crisafi B. Bellati F. Panici PB. Pain and ovarian endometrioma recurrence after laparoscopic treatment of endometriosis: a long-term prospective study.2010;93:716-21. Herr KA. Garand L. Assessment and measurement of pain in older adults. Clinics in geriatric medicine. 2001;17:457-73 Booker SQ. Haedtke C. Controlling pain and discomfort. Part 1: Assessment in Verbal Older Adults. Nursing.2016;46:65-8. Aziato L. Dedey F. Marfo K. Asamani JA. Clegg Lamptey JNA. Validation of three pain scales among adult postoperative patients in Ghana. BMC Nursing. 2015;14:42-51 Anaf V. Chapron C. Nakedi IE. Moor VD. Simonart T. Noel J. Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis. Fertil Steril. 2006;86:1336-43. Tulandi BAS, Prospective study of intraabdominal adhesion among women of different races with or without keloids. Am J Obset Gynecol. 2011; 204:132-6 Vercellini P.Trespid L. Giorgi OD. Cortesi I. Parazzini F. Crosignani P. Endometriosis and pelvic pain: relation to disease stage and localization. Fertil Steril. 1996;65:299-304. Tokushige N. Markham R. Russell P. Fraser I. Nerve fibres in peritoneal endometriosis. Hum Reprod Update. 2006;21:3001-7. Eshre. Management of women with endometriosis. Guideline of The European Society of Human Reproduction and Embriology;2013:5-95 Batzer F. GnRH analogs : options for endometriosis-associated pain treatment. Journal of minimally invasive gynecology.2006;13:539-45. Brown J. Pan A. Hart R. Gonadotropin-releasing hormone analogues for pain associated with endometriosis. Cochrane database of systematic reviews. 2010;12:1-115 Rcog. The investigation and management of endometriosis. Green-top Guidelines. 2008;24:1-14 Downloads Published How to Cite Issue Section License Copyright (c) 2020 Andalas Obstetrics And Gynecology Journal This work is licensed under a Creative Commons Attribution 4.0 International License.

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endometriosisadenomyosis

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