PPARy Expression in Eutopic and Ectopic Endometrium of Reproductive Age Women with Endometriosis

A. F. Dilmy, Muharam Natadisastra, Raden Muharam, Kanadi Sumapradja
In: Indonesian Journal of Obstetrics and Gynecology · 2016 · doi:10.32771/inajog.v3i4.55 · W2898225178
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This study quantified PPARy expression in eutopic and ectopic endometrium of women with endometriosis, finding no significant difference between the two sites.

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This cross-sectional study evaluated PPARγ receptor expression using two-step RT-qPCR in eutopic and ectopic endometrium from 10 reproductive-age women with endometriosis, with paired samples collected during laparoscopy or laparotomy (eutopic endometrium and endometriosis cyst wall). PPARγ transcripts were detected in both tissue types, but semiquantification showed no statistically significant difference between eutopic and ectopic endometrium (1.16 vs 1.25 relative fold; p=0.26). Pearson correlation indicated a weak positive correlation between PPARγ expression in eutopic and ectopic endometrium (r=0.16). This paper is centrally about endometriosis—PPARγ expression comparison between eutopic and ectopic endometrium.

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Abstract

Objective: To evaluate the expression of PPARy receptor and to compare its expression in eutopic and ectopic endometrium in women with endometriosis. Method: This is a cross sectional study. Ten female subjects with endometriosis that underwent laparoscopy or laparotomy who fulfilled the inclusion criteria were recruited by consecutive sampling. Two samples were taken, eutopic endometrium and ectopic endometrium from endometriosis cyst wall during surgery of each subject. PPARy expression was examined by two-step RT-qPCR. Our data was statistically examined using the paired t-test and Pearson’s correlation test. Result: PPARy was found to be expressed in eutopic and ectopic endometrium of women with endometriosis using the RT-qPCR method. The expression of PPARy was not statistically different in eutopic and ectopic endometrium (1.16 relative fold vs 1.25 relative fold; p=0.26). By Pearson’s correlation there was a weak positive correlation between PPARy expression of eutopic and ectopic endometrium (r=0.16). Conclusion: PPARy was detected by two-step RT-qPCR in eutopic and ectopic endometrium of women with endometriosis. Semiquantification of PPARy expression showed that there was no significant difference between PPARy expression in eutopic and ectopic endometrium of women with endometriosis. There was a weak positive correlation between PPARy expression in eutopic and ectopic endometrium of women with endometriosis. [Indones J Obstet Gynecol 2015; 3-4: 200-205] Keywords: endometriosis, PPARy, two-step RT-qPCR
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PPARy Expression in Eutopic and Ectopic Endometrium of Reproductive Age Women with Endometriosis DOI: https://doi.org/10.32771/inajog.v3i4.55Abstract Objective: To evaluate the expression of PPARy receptor and to compare its expression in eutopic and ectopic endometrium in women with endometriosis. Method: This is a cross sectional study. Ten female subjects with endometriosis that underwent laparoscopy or laparotomy who fulfilled the inclusion criteria were recruited by consecutive sampling. Two samples were taken, eutopic endometrium and ectopic endometrium from endometriosis cyst wall during surgery of each subject. PPARy expression was examined by two-step RT-qPCR. Our data was statistically examined using the paired t-test and Pearson’s correlation test. Result: PPARy was found to be expressed in eutopic and ectopic endometrium of women with endometriosis using the RT-qPCR method. The expression of PPARy was not statistically different in eutopic and ectopic endometrium (1.16 relative fold vs 1.25 relative fold; p=0.26). By Pearson’s correlation there was a weak positive correlation between PPARy expression of eutopic and ectopic endometrium (r=0.16). Conclusion: PPARy was detected by two-step RT-qPCR in eutopic and ectopic endometrium of women with endometriosis. Semiquantification of PPARy expression showed that there was no significant difference between PPARy expression in eutopic and ectopic endometrium of women with endometriosis. There was a weak positive correlation between PPARy expression in eutopic and ectopic endometrium of women with endometriosis. [Indones J Obstet Gynecol 2015; 3-4: 200-205] Keywords: endometriosis, PPARy, two-step RT-qPCRDownloads Download data is not yet available. Downloads Published 2015-10-14 Versions How to Cite Dilmy, A. F., Natadisastra, M., & Sumapradja, K. (2015). PPARy Expression in Eutopic and Ectopic Endometrium of Reproductive Age Women with Endometriosis. Indonesian Journal of Obstetrics and Gynecology, 3(4). https://doi.org/10.32771/inajog.v3i4.55 Issue Section Research Article

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endometriosis

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