Intraocular endometrium in the rabbit as a model for endometriosis
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Rabbit intraocular endometrium autografts survived up to 181 days, demonstrating vascularization, while human xenografts showed signs of immune rejection after 7 days.
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Abstract
The model described suggests that endometrium can be successfully transplanted to the rabbit eye and observed through a slit lamp for morphological changes such as vascularization. Sampling of aqueous humor in volumes adequate for biochemical measurements have been demonstrated. Autografts of rabbit endometrium survived for up to 181 days. Although xenografts of human endometrial and endometriotic tissue demonstrate some adherence and vascularization, there is indication of immune rejection by day 7. Other treatment regimens will be explored with the objective of prolonging the graft survival time.
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- europepmc
- last seen: 2026-06-18T06:15:08.409253+00:00
- pubmed
- last seen: 2026-05-13T22:11:44.647872+00:00
- unpaywall
- last seen: 2026-06-13T06:42:57.164913+00:00
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine