Clinicopathological Aspects of Dilation and Curettage (D&C) Biopsies Taken from Patients Living at High Altitude in Taif, KSA, with a Special Emphasis on Chronic Endometritis

Howaida M. Hagag, Khadiga Ahmed Ismail, Mashael Al‐Mutairi, Bushra I. Alnefaie, Seham Hazza Al-ajmani, Ashwaq M. Altalhi, Abdulaziz H. Alkhamash, Naïf Saad Althobaiti, Mohammed A. Al-Humaidi, Ahmed Abdulwahab Bawahab, Abdulkarim Hasan
In: Life · 2024 · vol. 14(8) , pp. 1021 · doi:10.3390/life14081021 · PMID:39202763 · W4401639630
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⚙ AI-generated summary by claude@2026-06, 2026-06-13 ⓘ

This study analyzed D&C biopsies from 100 women in Taif, Saudi Arabia, finding disordered proliferative endometrium as the most common pathology and an 8% prevalence of chronic endometritis.

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Abstract

BACKGROUND: Chronic endometritis (CE) is a persistent inflammation of the uterine lining. Although it has a minimal clinical presentation, CE adversely affects the reproductive ability of women. The aims of this study were to detect pathological endometrial patterns in D&C biopsies and to evaluate chronic endometritis in patients living in a high-altitude area (1800 m above sea level) in order to determine the clinical pathological features and prevalence. MATERIALS AND METHODS: A cross-sectional study conducted at King Faisal Maternity Hospital included 100 samples of D&C biopsies from women complaining of various gynecological symptoms not due to gestational causes. The biopsies underwent tissue processing, H&E staining, and CD138 detection. Blood samples were taken for serological detection of infectious diseases, complete blood count, and chemical parameters. RESULTS: -values of 0.05 and 0.02, respectively. It can be concluded that the most common gynecological complaint of women in this study was abnormal uterine bleeding. CONCLUSIONS: The most commonly diagnosed pathological endometrial disorder in D&C biopsies was disordered proliferative endometrium, followed by endometrial polyps and endometrial hyperplasia. All of these are usually associated with hormonal disturbance, which appeared to be very common in the women in this study. The prevalence of chronic endometritis detected in our study was 8%, which is relatively high.

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last seen: 2026-05-13T19:27:01.244207+00:00
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