Chondroid nodule in the female peritoneum arises from normal tissue and not from teratoma or conception product

The pathogenesis of benign-looking cartilaginous tissue within the peritoneum is unknown. Chondroid metaplasia of subcoelomic mesenchyme has been suggested, as has been the case for other gynecological diseases such as endometriosis, peritoneal leiomyomatosis, or gliomatosis peritonei, but has never been proven. Chondroid nodules in the peritoneum may represent either teratomatous tissue, fetal rests from a conception product, or metaplasia of pluripotent mesenchymal cells. Herein, the unique genetic characteristics of ovarian teratomas (homozygous at many polymorphic microsatellite loci) versus normal tissues (heterozygous at the same loci) were used to investigate the origin of chondroid nodules in the peritoneum. DNA samples extracted from paraffin-embedded normal peritoneal tissue and chondroid peritoneal nodules from two patients were studied. In both cases, chondroid and normal tissue showed heterozygosity at each informative microsatellite locus on different chromosomes, with a profile similar to the mother. These results indicate that peritoneal chondroid nodules arise within the peritoneum, presumably from pluripotent mesodermal stem cells, and are not related to teratomatous proliferation, or previous pregnancy. This finding shows once again the plasticity and metaplastic potential of stem cells within the peritoneal cavity.

Giardino L, Savoldi E, Pontieri F, Piattelli A, Tallarigo F (2006) Chondroid metaplasia in inflamed pulp tissue: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:e42–e45 Kohl SK, Simpson RJ, Wisecarver J (2009) Chondroid metaplasia mimicking recurrent squamous cell carcinoma of the head and neck. Ear Nose Throat J 88:E4 Boukas A, Joshi A, Jenkins A, Holliman D (2013) Extensive cartilaginous metaplasia of recurrent posterior fossa ependymoma: case report and review of the literature. Pediatr Neurosurg 49:93–98 Bedrosian SA, Goldman RL, Sung MA (1983) Heterotopic cartilage in prostate. Urology 21:536–537 Roth E, Taylor HB (1966) Heterotopic cartilage in the uterus. Obstet Gynecol 27:838–844 Fadare O, Bifulco C, Carter D, Parkash V (2002) Cartilaginous differentiation in peritoneal tissues: a report of two cases and a review of the literature. Mod Pathol 15:777–780 Vortmeyer AO, Devouassoux-Shisheboran M, Li G, Mohr V, Tavassoli F, Zhuang Z (1999) Microdissection-based analysis of mature ovarian teratoma. Am J Pathol 154:987–991 Scully RE, Young RH, Clement PB (1998) Mucinous tumors in: tumors of the ovary and maldeveloped gonads, fallopian tubes and broad ligament. In: Atlas of tumor pathology, 3rd edn. AFIP, Washington DC, pp 81–105 Hegde P (2014) Extragonadal omental teratoma: a case report. J Obstet Gynaecol Res 40:618–621 Ferguson AW, Katabuchi H, Ronnett BM, Cho KR (2001) Glial implants in gliomatosis peritonei arise from normal tissue, not from the associated teratoma. Am J Pathol 159:51–55 Donna A, Betta PG, Bianchi V et al (1991) A new insight into the histogenesis of ‘mesodermomas’--malignant mesotheliomas. Histopathology 19:239–244 Jakubowitz O (1925) Beitrag zur klinik und histologie der adenomyosis (adenomyohyperplasie) uteri interna; berlin: Inaug Diss Houang M, Merkur H, Russell P (2010) Chondroid metaplasia of the peritoneum. Pathology 42:585–587 Mutsaers SE, Birnie K, Lansley S, Herrick SE, Lim C-B, Prêle CM (2015) Mesothelial cells in tissue repair and fibrosis. Front Pharmacol 6:113 Patel RM, Weiss SW, Folpe AL (2006) Heterotopic mesenteric ossification: a distinctive pseudosarcoma commonly associated with intestinal obstruction. Am J Surg Pathol 30:119–122 Qasem SA, DeYoung BR (2014) Cartilage-forming tumors. Semin Diagn Pathol 31:10–20 Author information Authors and Affiliations Corresponding author Ethics declarations Conflict of interest The authors declare that they have no conflict of interest. Electronic supplementary material ESM 1 (GIF 95 kb) High Resolution Image (download TIF ) (TIFF 4688 kb) ESM 2 (GIF 96 kb) High Resolution Image (download TIF ) (TIFF 4917 kb) Rights and permissions About this article Cite this article Franceschi, T., Allias, F., Mauduit, C. et al. Chondroid nodule in the female peritoneum arises from normal tissue and not from teratoma or conception product. Virchows Arch 473, 115–119 (2018). https://doi.org/10.1007/s00428-018-2295-3 Received: Revised: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s00428-018-2295-3