The effect of topical endometrial scratching on pregnancy outcome in women with previous failure of intrauterine insemination: A non-randomized clinical trial.

Farahnaz Farzaneh, Khastehfekr F
International journal of reproductive biomedicine · 2021 · doi:10.18502/ijrm.v19i5.9256 · PMID:34278200 · PMC8261094
Non-randomised trial OA: gold CC-BY-4.0
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⚙ AI-generated summary by qwen3.7-flash, 2026-10-13 ⓘ

This non-randomized trial found no significant difference in pregnancy rates between women with previous intrauterine insemination failure who received endometrial scratching and those receiving routine treatment alone.

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This non-randomized clinical trial evaluated whether topical endometrial scratching improves pregnancy outcomes in 336 infertile women who had previously failed intrauterine insemination. The study compared a treated group receiving the procedure against a control group undergoing standard care, finding no statistically significant difference in pregnancy rates between the two cohorts. Although some prior literature suggests benefits from such injury, this specific investigation concluded that local endometrial scratching does not enhance fertility success in this patient population. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

BackgroundThe prevalence of infertility is increasing worldwide and the treatment is one of the important issues.ObjectiveThis study aimed to evaluate the effect of local endometrial scratching on pregnancy outcomes in women with previous failure of intrauterine insemination.Materials and methodsThis non-randomized clinical trial study was performed on 336 women referred to the infertility clinic of Ali ebn-e Abitaleb Hospital of Zahedan (between May and November 2019). Women were divided into two groups: endometrial scratch as case and a control group. In the case group (n = 173), endometrial scratching was performed on days 8-9 of the menstrual cycle in addition to routine infertility treatments, while in the control group (n = 163), only routine treatment was performed. Chi-square test was used to compare the frequency of male factor severity and the percentage of successful pregnancies between both groups and was used to investigate the effect of male factor on the fertility rate in each group (moderate male factor and mild male factor).ResultsThe mean age of the women was 28.4 ± 5.2 yr. The success rate of pregnancy in the case group was 12.3% and in the control group 11%, which were not statistically significant (p = 0.697).ConclusionOverall, the results of this study showed that endometrial scratching had no effect on the pregnancy rate.
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Overall, the results of this study showed that endometrial scratching had no effect on the fertility rate. Since the results of the studies in this case are contradictory, it is recommended that further studies be conducted with larger sample size.

Coi Statement

The authors declare no conflict of interest regarding the publication of this paper

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