The expression of fractalkine in the endometrium during the menstrual cycle

M Watanabe, Mikio Watanabe, Koichiro Shimoya, K Shimoya, Q. Zhang, Kumiko Temma‐Asano, K Temma-Asano, Tadashi Kimura, T Kimura, Y Murata, Yuji Murata
International Journal of Gynecology & Obstetrics · 2006 · vol. 92(3) , pp. 242–247 · doi:10.1016/j.ijgo.2005.12.012 · PMID:16430900 · W2033785288
Other OA: closed CC0 ⤵ 3 in-corpus citations
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Fractalkine protein and mRNA were detected in the human endometrium, with significantly higher expression levels in the secretory phase compared to the proliferative phase.

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Abstract

OBJECTIVE: The objective of the study was to evaluate the presence of fractalkine in the endometrium of the uterus and the change of fractalkine protein levels during menstrual cycle. METHODS: Twelve samples of endometrium of the uterus were obtained from gynecological patients who underwent total hysterectomy. Western blotting, RT-PCR and immunohistochemistry were performed. RESULTS: Fractalkine protein was detected in the endometrium of the uterus. Positive staining was confirmed in the epithelial cells and grandular cells in the endometrium. Expression levels of fractalkine protein and mRNA in the endometrium during secretory phase were significantly higher than those during proliferative phase. Immunohistochemical analysis using an anti-CX3CR1 antibody demonstrated positive staining in the glandular cells of the endometrium of the uterus. CONCLUSION: Fractalkine was expressed in the endometrium and its production was up-regulated during secretory phase.

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MeSH descriptors

Chemokines, CX3C Endometrium Gene Expression Regulation Membrane Proteins Menstrual Cycle Receptors, Chemokine Adult Analysis of Variance Biomarkers Biomarkers Biopsy, Needle Blotting, Western Chemokine CX3CL1 Chemokines, CX3C Chemokines, CX3C CX3C Chemokine Receptor 1 Endometrium Endometrium Female Humans

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License: CC0 · commercial use OK