Medical and social portrait and clinical features of patients with endometrial hyperplasia

O. V. Safronov, Э.А. Казачкова, Е. Л. Казачков, L. E. Safronova, И. В. Сафронова
In: Ural Medical Journal · 2022 · vol. 20(6) , pp. 43–50 · doi:10.52420/2071-5943-2021-20-6-43-50 · W4220767293
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This retrospective study compared endometrial hyperplasia patients from 2016-2018 to 2006-2008, finding today's patients are younger, have later menarche, more urinary/GI issues, fewer STIs, lower parity, and more complicated births.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This retrospective study compared the medical and social profiles and clinical features of 52 women with endometrial hyperplasia without atypia treated in 2016–2018 versus 52 women treated in 2006–2008, framing changes as clinical “pathomorphosis.” Modern patients were characterized by an earlier disease onset, later menarche, a somatic burden dominated by urogenital and gastrointestinal conditions, a higher prevalence of non-inflammatory gynecologic disorders over sexually transmitted infections, low parity, more complicated deliveries with more preterm births, and heavy menstrual bleeding as the main symptom. The authors note that the high frequency of association with chronic endometritis aligns with other modern findings, but they also observed a trend toward more asymptomatic cases alongside heavy bleeding. The paper does not explicitly discuss endometriosis or adenomyosis, but it relates to endometriosis/adenomyosis research indirectly by evaluating chronic endometritis and clinical pathomorphosis patterns in endometrial hyperplasia, conditions that are reported as comorbid within broader pelvic inflammatory and endometrial pathology literature.

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Abstract

Introduction. Today more and more attention is paid to the influence of various external factors and health status on the development of specific features of the course of different diseases, that is to the pathomorphosis in its clinical (narrow) sense. The aim of the study was comparative analysis of the medical and social profile and clinical features of the patients with endometrial hyperplasia (EH) without atypia in the cohorts of 2016-2018 and 2006-2008 in the light of the pathomorphosis study. Materials and methods. A retrospective study of medical and social profile and clinical features of EH without atypia has been performed in 52 patients who were under observation in 2016 – 2018 (1st group) and in 52 women who underwent medical treatment of this disease in 2006-2008 (2nd group) to investigate the problem of EH without atypia from the point of view of the pathomorphosis study. Results. The following are the characteristic features of today’s patients with EH without atypia: younger age of disease development, specific formation of menstrual function (a later menarche), specific somatic status (predominance of the diseases of the urinary system and gastrointestinal tract), predominance of non-inflammatory diseases of the reproductive organs over sexually transmitted infections, low parity, complicated course of labor (increase in the proportion of premature delivery). Heavy menstrual bleeding (HMB) was the main clinical manifestation of the EH without atypia. Discussion. Our data on the clinical picture of EH without atypia and the high frequency of the combination of EH with chronic endometritis coincide with the results of other modern studies. However, at present, in the clinical picture of EH, along with HMB, we observe a tendency to an increase in the frequency of asymptomatic EH, and the revealed high frequency of the combination of EH with chronic endometritis confirms the conclusions of a number of researchers about the important role of chronic endometritis in the formation of EH. Conclusions. The above stated specific features of the medical and social profile and clinical course of the EH without atypia could be interpreted as pathomorphosis in the clinical (narrow) sense.

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