Fundamental research into endometriosis: what areas, what avenues?

Carole Abo; Guillaume Parpex; Mathilde Bourdon; Chloé Maignien; Bruno Borghese; Piétro Santulli; Louis Marcellin; Charles Chapron

doi:10.1684/mte.2023.0951

Fundamental research into endometriosis: what areas, what avenues?

Carole Abo, Guillaume Parpex, Mathilde Bourdon, Chloé Maignien, Bruno Borghese, Piétro Santulli, Louis Marcellin, Charles Chapron

In: Médecine de la Reproduction · 2023 · vol. 25(2) , pp. 149–165 · doi:10.1684/mte.2023.0951 · W4385882498

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⚙ AI-generated summary by claude@2026-06+body, 2026-06-12 ⓘ

This review explores current fundamental research areas and potential future avenues for understanding endometriosis, a common gynecological condition defined by endometrial tissue outside the uterus.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

This 2023 paper surveys fundamental research directions in endometriosis, describing what areas of study exist and “which avenues” researchers are pursuing to understand the disease. It frames endometriosis as endometrial tissue outside the uterine cavity and provides prevalence estimates (about 10% in reproductive-age women, potentially higher—up to 50%—among those with infertility and/or chronic pelvic pain), noting that asymptomatic disease may lead to underestimation. The paper’s key finding is a structured overview of major research axes rather than a single new experimental result, and it does not present new data, with the main limitation being that it is a narrative synthesis. This paper is centrally about endometriosis — it focuses on mapping fundamental research areas and future research avenues for endometriosis.

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Médecine de la Reproduction MENURecherche fondamentale en endométriose : quels axes, quelles pistes ? Volume 25, numéro 2, Avril-Mai-Juin 2023 Illustrations 1 Service de chirurgie gynécologie obstétrique II et médecine de la reproduction, hôpital universitaire Paris Centre (HUPC), centre hospitalier universitaire (CHU) Cochin, Paris, France 2 Université Paris-Cité, faculté de médecine, Paris, France; AP-HP, Paris, France 3 Genomics, Epigenetics and Physiopathology of Reproduction Team, Department of Development, Reproduction and Cancer, INSERM U1016, Paris, France 4 Oxidative Stress, Cellular Proliferation and Inflammation Team, Department of Development, Reproduction and Cancer, Inserm U1016, Paris, France * Tirés à part : C. Abo - DOI : 10.1684/mte.2023.0951 - Page(s) : 149-65 - Année de parution : 2023 L’endométriose, définie par la présence de tissu endométrial en dehors de la cavité utérine, est l’une des pathologies gynécologiques les plus fréquentes [1]. On estime sa prévalence à environ 10 % [2, 3] dans la population des femmes en âge de procréer, mais elle pourrait s’élever jusqu’à 50 % chez les patientes infertiles et/ou souffrant de douleurs pelviennes chroniques [4–7]. D’autre part, l’existence de formes asymptomatiques de la maladie participe à cette sous-estimation.L’une des spécificités [...]

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