Analysis of p53 and c-erbB-2 expression in ovarian endometrioid carcinomas arising in endometriosis

Federico Prefumo, Pier Luigi Venturini, Venturini PL, Ezio Fulcheri
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2003 · doi:10.1097/00004347-200301000-00016 · PMID:12496703
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Ovarian endometrioid carcinomas arising in endometriosis showed significantly higher expression of p53 and c-erbB-2, with a significant association between these proteins, unlike tumors without associated endometriosis.

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Abstract

We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p = 0.015 and p = 0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p = 0.013) but not in group 2 (p = 0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.
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Original Contributions Analysis of p53 and c-erbB-2 Expression in Ovarian Endometrioid Carcinomas Arising in Endometriosis - Federico Prefumo - Pier Luigi Venturini - Ezio Fulcheri International Journal of Gynecological Pathology 22(1):p 83-88, January 2003. Summary: We assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p=0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis. Copyright ©2003International Society of Gynecological Pathologists

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Endometrioid Endometriosis Genes, erbB-2 Genes, p53 Ovarian Neoplasms Adult Aged Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometriosis Endometriosis Endometriosis Female Genes, erbB-2 Genes, p53 Humans Immunohistochemistry Middle Aged

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