{"paper_id":"2f97f2a9-9b79-4a9d-a32a-de32177064b5","body_text":"Original Contributions\nAnalysis of p53 and c-erbB-2 Expression in Ovarian Endometrioid Carcinomas Arising in Endometriosis\n- Federico Prefumo\n- Pier Luigi Venturini\n- Ezio Fulcheri\nInternational Journal of Gynecological Pathology 22(1):p 83-88, January 2003.\nSummary:\nWe assessed the immunohistochemical expression of p53 and c-erbB-2 oncoproteins in 13 ovarian endometrioid adenocarcinomas arising from endometriosis (group 1) and compared the findings with 15 otherwise similar cases without associated endometriosis (group 2). Tumors in group 1 showed a higher expression of both p53 and c-erbB-2 (p=0.015 and p=0.048, respectively). The expression of the two proteins was also significantly associated in group 1 (p=0.013) but not in group 2 (p=0.63) tumors. The different pattern of expression of p53 and c-erbB-2 in the two groups suggests that different molecular pathways may be involved in their pathogenesis.\nCopyright ©2003International Society of Gynecological Pathologists","source_license":"public-domain-us","license_restricted":false}