Malignant transformation of extragonadal endometriosis: a case report.

W C Wu, Wu WC, Wei Wu, Hsiao MW, M W Hsiao, J. C. Ye, Ye JC, Yao‐Ching Hung, Hung YC, Y C Hung, W C Chang, Wan‐Chun Chang, Chang WC
European journal of gynaecological oncology · 2009 · vol. 30(5) , pp. 563–5 · PMID:19899417 · W2405991787
article OA: closed CC0 ⤵ 5 in-corpus citations
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This case report details the malignant transformation of extragonadal endometriosis into endometrioid adenocarcinoma in a 39-year-old woman, confirmed histologically and successfully managed with surgery and chemotherapy.

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Abstract

Though malignant transformation of endometriosis has been documented, malignancy arising from extragonadal endometriosis is rare. We present the case of a 39-year-old woman with abdominal pain and fullness after menstruation. Evaluation revealed a cul-de-sac mass and CA-125 level of 1048 U/ml. A hysterectomy, bilateral salpingo-oophorectomy, and omentectomy were performed. Endometrioid adenocarcinoma with a clearly defined transition zone from endometriosis to adenocarcinoma was noted histologically. Adjuvant chemotherapy and GnRH agonist treatment was administered. Serum CA-125 level was 1.51 U/ml 19 months after completion of treatment. Patients with endometriosis and elevated CA-125 levels should be managed aggressively and CA-125 levels monitored until they have normalized.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma, Endometrioid Cell Transformation, Neoplastic Endometriosis Hyperplasia Peritoneal Neoplasms Adult Carcinoma, Endometrioid Endometriosis Female Humans Hyperplasia Peritoneal Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (5)

Source provenance

europepmc
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License: CC0 · commercial use OK