Metabolic syndrome in reproductive age: A cross-sectional study

Aringazina R, Raisa Aringazina, Nurgul Zholdassova, Zholdassova N, Gulshara Berdesheva, Berdesheva G, Zhansulu Nurgaliyeva, Nurgaliyeva Z, Gulnara Kurmanalina, Kurmanalina G, Zhanalina B, Bakhyt Zhanalina, Sharlovych Z, Zoia Sharlovych
International journal of reproductive biomedicine · 2025 · vol. 23(5) , pp. 383–396 · doi:10.18502/ijrm.v23i5.19262 · PMID:40989083 · PMC12413543
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This cross-sectional study analyzed metabolic syndrome features in 140 reproductive-age adults, finding significant testosterone differences between cases and controls but no stable hormonal trends suitable for diagnosis.

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This cross-sectional study analyzed metabolic syndrome characteristics and sex hormone levels in 140 reproductive-age adults aged 35 to 49, comparing individuals with the condition against healthy controls. The researchers measured anthropometric data, biochemical markers, and estradiol or testosterone levels to assess how metabolic disorders influence fertility potential in both men and women. Key findings highlighted significant differences in hormonal profiles and metabolic parameters between the groups, linking obesity-related inflammation and insulin resistance to reduced conception chances and sexual dysfunction. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

BACKGROUND: Obesity and metabolic syndrome (MetS), as components of excess body weight, have reached global epidemic levels. OBJECTIVE: The study aimed to investigate the features of the MetS course in men and women of reproductive age. MATERIALS AND METHODS: This cross-sectional study was conducted with 140 participants aged between 35 and 49 yr at City Polyclinics No. 1, 3, and 4, Aktobe, Kazakhstan from March 2016-2019. Participants were divided into 2 subgroups based on diagnosis of MetS. The case group (with MetS), and the control group (without MetS) (n = 70/each consisted of 40 women and 30 men). Anthropometric, instrumental, and laboratory methods were used to confirm the diagnosis of MetS and determine its features in both groups. RESULTS: The results showed an increase in the uric acid level in the blood to 431.00 ± 66.37 μ mol/L and 5.47 ± 0.90 mol/day in the urine. Dyslipidemia was also noted in the case group of individuals with high-density lipoprotein levels of 1.22 ± 0.27 mmol/L vs. 1.32 ± 0.47 mmol/L in the control group. The testosterone level was 16.4 ± 3.04 nmol/L in the case group and 20.3 ± 5.6 nmol/L in the control. The difference in testosterone level was found to be statistically significant (p < 0.01). CONCLUSION: The analysis of sex hormone levels did not reveal any stable trends that could be considered diagnostic. That may indicate a correlation with the reproductive age characteristics of the examined individuals (men and women): significant differences between hormone levels were fixed in the case and control groups.
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R. Aringazina: Was a developer of the research design and conception, curated analyzing of the data processing, had a part in the manuscript creation, analysis, and paper correcting. N. Zholdassova: Had a part in research design creation, research data collecting and processing, and she was the creator of the methodology and results parts of the manuscript. G. Berdesheva: Had a part in the research data analysis and interpretation, created the discussion section of the manuscript. Zh. Nurgaliyeva: Had a part in the research data processing and was the main in statistical processing of the collected data; she was responsible for translating the raw manuscript text into English. G. Kurmanalina: Collected, analyzed, and had a part in interpreting research data, was responsible for the introduction section creation. B. Zhanalina: Had made previous review and critical analysis of the main part of the research, had a part in paper correction and creation. Z. Sharlovych: Analyzed and processed research data, made a previous review of the manuscript before sending it to the journal's edition. All of the authors read and approved the final variant of the manuscript before it was sent for consideration.

Coi Statement

The authors declare that there is no conflict of interest.

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