Twin pregnancy after preimplantation diagnosis for sex selection

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This paper reports a twin female pregnancy achieved through preimplantation genetic diagnosis to avoid X-linked hemophilia in a carrier.

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Abstract

A twin female pregnancy was obtained in a haemophilia carrier after two preimplantation diagnosis cycles. The embryonic sex of biopsied blastomeres was determined with the use of dual fluorescence in-situ hybridization with directly labelled DNA probes specific for the X and Y chromosome. A twin female pregnancy was confirmed by means of ultrasonography and amniocentesis at the 14th week of amenorrhoea. The patient delivered two healthy females by Caesarian section at the 37th week of pregnancy.

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Condition tags

endometriosis

MeSH descriptors

Embryonic Development Hemophilia A Pregnancy Complications, Hematologic Prenatal Diagnosis Sex Determination Analysis Twins Adult Amniocentesis Blastomeres Blastomeres DNA Probes Endometriosis Endometriosis Female Fertilization in Vitro Hemophilia A Hemophilia A Hemophilia A Heterozygote Humans

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Source provenance

europepmc
last seen: 2026-09-13T09:25:22.628771+00:00
pubmed
last seen: 2026-05-13T22:11:24.284338+00:00
unpaywall
last seen: 2026-09-14T06:35:54.356137+00:00
License: public-domain-us · commercial use OK · attribution required
Courtesy of the U.S. National Library of Medicine