Cutaneous Endometriosis: A Differential Diagnosis of Umbilical Nodule

Mariana Batista, Batista M, Alves F, Francisca Alves, José Cardoso, José Carlos Cardoso, Cardoso J, Gonçalo M, Margarida Gonçalo
Acta medica portuguesa · 2020 · vol. 33(4) , pp. 282–284 · doi:10.20344/amp.10966 · PMID:32238243 · W3014317250
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper presents a case of an umbilical nodule in a nulliparous woman, diagnosed as cutaneous endometriosis via skin biopsy, highlighting its differential diagnostic importance and potential association with pelvic disease.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The paper reports a case of cutaneous endometriosis presenting as an acute painful umbilical nodule in a nulliparous woman, with a surrounding painful periumbilical subcutaneous plaque and slow enlargement over days, and notes two similar prior episodes. A skin biopsy with histopathologic examination supported the diagnosis of endometriosis. The article also reviews this rare form of endometriosis, emphasizing that it is frequently associated with pelvic disease and that recognition matters for fertility outcomes, while the main limitation is that evidence is based on a single case report plus a narrative review. This paper is centrally about endometriosis — it describes and reviews cutaneous (umbilical) endometriosis as a differential diagnosis of an umbilical nodule.

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Abstract

Endometriosis is a chronic disorder characterized by the presence of ectopic functional endometrial tissue outside the uterine cavity and which affects about 10% of all women of reproductive age. Cutaneous endometriosis, usually localized in the abdominal wall, is a rare entity. We report the case of a nulliparous woman with an acute painful umbilical nodule that slowly increased in size during the days prior to observation. The lesion was surrounded by a painful periumbilical subcutaneous plaque. The patient denied associated constitutional symptoms and reported two similar episodes in the previous two years. A skin biopsy was performed, and histopathologic examination was consistent with the diagnosis of endometriosis. This article reviews this disease particularly rare in nulliparous and highlights the importance of recognizing this clinical presentation of endometriosis due to its frequent association with pelvic disease that can lead to reduced fertility.
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Cutaneous Endometriosis: A Differential Diagnosis of Umbilical Nodule DOI: https://doi.org/10.20344/amp.10966Keywords: Endometriosis, Skin Diseases/diagnosis, UmbilicusAbstract Endometriosis is a chronic disorder characterized by the presence of ectopic functional endometrial tissue outside the uterine cavity and which affects about 10% of all women of reproductive age. Cutaneous endometriosis, usually localized in the abdominal wall, is a rare entity. We report the case of a nulliparous woman with an acute painful umbilical nodule that slowly increased in size during the days prior to observation. The lesion was surrounded by a painful periumbilical subcutaneous plaque. The patient denied associated constitutional symptoms and reported two similar episodes in the previous two years. A skin biopsy was performed, and histopathologic examination was consistent with the diagnosis of endometriosis. This article reviews this disease particularly rare in nulliparous and highlights the importance of recognizing this clinical presentation of endometriosis due to its frequent association with pelvic disease that can lead to reduced fertility. Downloads Downloads Published How to Cite Issue Section License All the articles published in the AMP are open access and comply with the requirements of funding agencies or academic institutions. The AMP is governed by the terms of the Creative Commons ‘Attribution – Non-Commercial Use - (CC-BY-NC)’ license, regarding the use by third parties. It is the author’s responsibility to obtain approval for the reproduction of figures, tables, etc. from other publications. Upon acceptance of an article for publication, the authors will be asked to complete the ICMJE “Copyright Liability and Copyright Sharing Statement “(http://www.actamedicaportuguesa.com/info/AMP-NormasPublicacao.pdf) and the “Declaration of Potential Conflicts of Interest” (http:// www.icmje.org/conflicts-of-interest). An e-mail will be sent to the corresponding author to acknowledge receipt of the manuscript. After publication, the authors are authorised to make their articles available in repositories of their institutions of origin, as long as they always mention where they were published and according to the Creative Commons license.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Skin Diseases Umbilicus Diagnosis, Differential Endometriosis Female Humans Skin Diseases Umbilicus Young Adult

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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