INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES

S. V. Shramko, В. Н. Зорина, Zorin Na, I. A. Botvinyeva, С. В. Архипова, V. V. Likhacheva
In: Medical Immunology (Russia) · 2018 · vol. 20(5) , pp. 731–738 · doi:10.15789/1563-0625-2018-5-731-738 · W2900197509
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This study compared steroid receptor gene expression and serum immunoregulatory proteins, cytokines, and sex steroids in uterine leiomyoma, adenomyosis, and leiomyosarcoma patients, finding distinct expression patterns and altered protein/cytokine levels.

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The study examined how steroid receptor gene expression in uterine tissues relates to circulating levels of immunoregulatory proteins, cytokines, and sex steroids in women with proliferative uterine diseases, using a combined tissue/serum immunoendocrine assessment. The key reported finding was the existence of interrelationships between the expression of steroid receptor genes and serum concentrations of these immunoregulatory mediators and sex hormones, indicating coordinated regulation in proliferative pathology. The paper’s main limitation, as implied by its framing, is that it focuses on associations between markers rather than establishing causal mechanisms. Relevance to endometriosis: the article is included in the corpus through its explicit discussion of adenomyosis and its interrelation with uterine proliferative conditions in the literature it cites, though the study itself centers on steroid receptor genes and systemic cytokine/sex-steroid profiles across proliferative uterine diseases.

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Abstract

Pathogenetic mechanisms of uterine leiomyoma, adenomyosis and their combination are complicated and poorly understood, a differential diagnosis of leiomyosarcoma of the uterus is difficult. Our study aimed for a comparative analysis of the serum contents of α2-MG, PAG, some cytokines, sex steroids and the expression of steroid receptor genes in the patients with different variants of uterine proliferative diseases, in order to determine their pathological role, diagnostic and prognostic value. Expression of estrogen receptor genes adenomyosis nodes was 1.5 to 2-fold higher than in leiomyoma, the combined pathology showed intermediate values, and expression of ER and PGR genes in leiomyosarcoma was minimal. In cellular leiomyoma, expression of ER receptor genes in the surrounding myometrium was 2 to 3-fold higher than in cases of simple leiomyomas. At the same time, concentration of estrogen and progesterone in the blood is comparable between the groups and control groups. All the patients have a deficiency of immunomodulatory α2-MG (12-13% for leiomyomas, 20% for adenomyosis, and 23% for malignant pathology). The concentration of immunosuppressive PAG is increased in combined conditions and leiomyosarcoma. In addition, the contents of IL-6 and TNFα increase, the VEGF levels exceed normal values 4 to 4.5-fold, in leiomyoma, 5.5-fold, in combined pathology, 6.5, in adenomyosis, and 10-fold, in leiomyosarcoma.The obtained results confirm that immunomodulatory proteins, cytokines and cell-targeting sex hormones exert an interdependent influence upon each other in the studied diseases, and their significant changes may be used in diagnostics and prognosis.
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ВЗАИМОСВЯЗЬ ЭКСПРЕССИИ ГЕНОВ СТЕРОИДНЫХ РЕЦЕПТОРОВ В ТКАНЯХ МАТКИ И СЫВОРОТОЧНЫХ КОНЦЕНТРАЦИЙ ИММУНОРЕГУЛЯТОРНЫХ БЕЛКОВ, ЦИТОКИНОВ, ПОЛОВЫХ СТЕРОИДОВ ПРИ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЯХ https://doi.org/10.15789/1563-0625-2018-5-731-738 Аннотация Об авторах C. В. ШрамкоРоссия к.м.н., доцент кафедры акушерства и гинекологии. Новокузнецк.В. H. Зорина Россия д.б.н., главный научный сотрудник НИЛ иммунологии. 654005, Россия, г. Новокузнецк, пр. Строителей, 5.H. А. Зорин Россия д.б.н., профессор, заведующий НИЛ иммунологии. Новокузнецк.И. А. Ботвиньева Россия к.б.н., заведующая клинико-диагностической лабораторией. Новокузнецк.С. В. Архипова Россия к.м.н., старший научный сотрудник НИЛ иммунологии. Новокузнецк.В. В. Лихачева Россия к.м.н., ассистент кафедры акушерства и гинекологии. Новокузнецк.Список литературы 1. Барышников А.Ю., Шишкин Ю.В. Программированная клеточная смерть (апоптоз) // Российский онкологический журнал, 1996. № 1. С. 64-66. 2. Гуриев Т.Д., Сидорова И.С., Унанян А.Л. Сочетание миомы матки и аденомиоза. М.: МИА, 2012. 251 c. 3. Зорин Н.А., Зорина В.Н. Эволюция белков семейства макроглобулинов – от бактерий до приматов // Журнал эволюционной биохимии и физиологии, 2017. Т. 53, № 6. С. 389-397. 4. Левченко В.Г., Зорина В.Н., Баженова Л.Г., Зорина Р.М., Зорин Н.А. Некоторые аспекты патогенеза преэклампсии у беременных // Российский вестник акушера-гинеколога, 2010. Т. 10, № 3. C. 21-25. 5. Печеникова В.А., Акопян Р.А., Кветной И.М. К вопросу о патогенетических механизмах развития и прогрессии внутреннего генитального эндометриоза – аденомиоза // Журнал акушерства и женских болезней, 2015. Т. LXIV, вып. 6. C. 51-57. 6. Родионова М.В., Воротников И.К., Родионов В.В., Чхиквадзе Н.В., Дудко Е.А., Рябчиков Д.А., Ошкина Е.В., Богуш Т.А. Эстрогеновые рецепторы бета как маркеры эффективности гормональной терапии рака молочной железы // Российский биотерапевтический журнал, 2015. Т. 14, № 2. C. 39-46. 7. Сидорова И.С., Унанян А.Л., Агеев М.Б., Ведерникова Н.В., Жолобова Н.М. Современное состояние вопроса о патогенезе, клинике, диагностике и лечении миомы матки у женщин репродуктивного возраста // Акушерство, гинекология, репродукция, 2012. Т. 6, № 4. С. 22-28. 8. Стрижаков А.Н., Давыдов А.В., Пашков В.М., Лебедев В.А. Доброкачественные заболевания матки. М.: ГЭОТАР-Медиа, 2014. 304 c. 9. Сысоев К.А., Кулагина Н.В., Тотолян А.А. Особенности экспрессии цитокинов в перитонеальной жидкости у больных с лейомиомой матки // Медицинская иммунология, 2006. Т. 8, № 4. С. 547-556. doi: 10.15789/1563-0625-2006-4-547-556. 10. Cui R.R., Wright J.D., Hou J.Y. Uterine leiomyosarcoma: a review of recent advances in molecular biology, clinical management and outcome. BJOG, 2017, Vol. 124, no. 7, pp. 1028-1037. 11. Foca C., Moses E.K., Quinn M.A., Rice G.E. Differential expression of the alpha(2)-macroglobulin receptor and the receptor associated protein in normal human endometrium and endometrial carcinoma. Mol. Hum. Reprod., 2000, Vol. 6, no. 10, pp. 921-927. 12. Kobayashi H., Uekuri C., Akasaka J., Ito F., Shigemitsu A., Koike N., Shigetomi H. The Biology of uterine sarcomas: A review and update. Mol. Clin. Oncol., 2013, Vol. 1, no. 4, pp. 599-609. 13. Manta L., Suciu N., Toader O., Purcărea R.M. Constantin A., Popa F. The etiopathogenesis of uterine fibromatosis. J. Med. Life., 2016, Vol. 9, no. 1, pp. 39-45. 14. Plewka D., Marczyński J., Morek M., Bogunia E., Plewka A. Receptors of hypothalamic-pituitary-ovarianaxis hormone in uterine myomas. Biomed. Res. Int., 2014, Vol. 2014, 521313. doi: 10.1155/2014/521313. 15. Zhang Q., Ubago J., Li L., Guo H., Liu Y., Qiang W., Kim J.J., Kong B., Wei J.J. Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma. Cancer, 2014, Vol. 120, no. 20, pp. 3165-3177. Рецензия Для цитирования: Шрамко C.В., Зорина В.H., Зорин H.А., Ботвиньева И.А., Архипова С.В., Лихачева В.В. ВЗАИМОСВЯЗЬ ЭКСПРЕССИИ ГЕНОВ СТЕРОИДНЫХ РЕЦЕПТОРОВ В ТКАНЯХ МАТКИ И СЫВОРОТОЧНЫХ КОНЦЕНТРАЦИЙ ИММУНОРЕГУЛЯТОРНЫХ БЕЛКОВ, ЦИТОКИНОВ, ПОЛОВЫХ СТЕРОИДОВ ПРИ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЯХ. Медицинская иммунология. 2018;20(5):731-738. https://doi.org/10.15789/1563-0625-2018-5-731-738 For citation: Shramko S.V., Zorina V.N., Zorin N.A., Botvinyeva I.A., Arkhipova S.V., Likhacheva V.V. INTERRELATION OF STEROID RECEPTOR GENE EXPRESSION IN UTERINE TISSUES AND SERUM CONCENTRATIONS OF IMMUNOREGULATORY PROTEINS, CYTOKINES, SEX STEROIDS IN PROLIFERATIVE DISEASES. Medical Immunology (Russia). 2018;20(5):731-738. (In Russ.) https://doi.org/10.15789/1563-0625-2018-5-731-738 JATS XML

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