Cellular retinol‐binding protein‐1 expression in endometrial stromal cells: physiopathological and diagnostic implications

A Orlandi, Augusto Orlandi, A Ferlosio, Amedeo Ferlosio, A Ciucci, Alessandro Ciucci, F Sesti, Francesco Sesti, B Lifschitz-Mercer, Beatriz Lifschitz‐Mercer, Giulio Gabbiani, G Gabbiani, Luigi Giusto Spagnoli, L G Spagnoli, B Czernobilsky, Bernard Czernobilsky
Histopathology · 2004 · vol. 45(5) , pp. 511–517 · doi:10.1111/j.1365-2559.2004.01963.x · PMID:15500655 · W2081047184
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Cellular retinol-binding protein-1 (CRBP-1) expression in endometrial stromal cells varies with physiological state and location, appearing more specific than CD10 and potentially serving as an adjuvant marker for stromal changes.

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Abstract

AIMS: Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiated state of the endometrium through retinol bioavailability regulation. The aim was to analyse CRBP-1 expression in endometrial stromal cells at eutopic and ectopic sites in different physiopathological conditions. METHODS AND RESULTS: Antibodies to CRBP-1, CD10 and alpha-smooth muscle actin were applied to proliferative (n = 10), secretory (n = 9) and atrophic (n = 7) endometrium, decidua (n = 4), adenomyosis (n = 5), endometriosis (n = 10), endometrial polyps (n = 9), simple endometrial hyperplasia (n = 6), well-differentiated endometrioid carcinoma (n = 6) and submucosal leiomyomas (n = 5). In some cases, Western blotting and reverse transcription-polymerase chain reaction were also applied. CRBP-1 was expressed by eutopic and ectopic endometrial stromal cells more markedly during the late secretory phase and in decidua of pregnancy. CRBP-1 expression was low in the stroma of atrophic endometrium and absent in myometrium, leiomyomas and cervical stroma. CD10 immunoreactivity was weak in atrophic endometrium and in decidua. CONCLUSIONS: CRBP-1 expression characterizes endometrial stromal cells at eutopic and ectopic sites and appears to be more specific than CD10. The level of CRBP-1 varies in intensity according to hormonal variations, reaching its maximum in predecidua and decidua. Thus, immunodetection of CRBP-1 may help to elucidate the physiopathological changes which occur in endometrial stroma and can also be applied as an adjuvant stromal marker.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometrium Retinol-Binding Proteins Adult Aged Biomarkers Endometrium Endometrium Endometrium Female Humans Middle Aged Neprilysin Neprilysin Retinol-Binding Proteins Retinol-Binding Proteins Retinol-Binding Proteins, Cellular Stromal Cells Stromal Cells

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