High CA-125 in Endometrioma: An Unusual Presentation

Raihana Musawwir, Sheuly Akhter, Fatema Begum
In: KYAMC Journal · 2018 · vol. 9(3) , pp. 139–140 · doi:10.3329/kyamcj.v9i3.38788 · W2903050651
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This paper describes a 36-year-old woman with a large abdominal mass and pain, who presented with a very high CA-125 level of 3500 U/mL, but was found to have a ruptured endometrioma without malignancy upon laparotomy.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-16 · read from full text ⓘ

This case report describes a 36-year-old woman with a large abdominal mass and abdominal pain in whom plasma CA-125 was markedly elevated to 3500 U/mL, leading clinicians to suspect ovarian malignancy. During laparotomy, a ruptured ovarian endometrioma was identified, and histopathology reported no malignancy. The authors emphasize a key caveat that very high CA-125 levels are usually suggestive of ovarian malignancy but can rarely occur in benign female genital tract conditions, including endometriosis/endometrioma. This paper is centrally about endometriosis — it reports an unusual endometrioma presentation with extremely high CA-125 that mimicked ovarian cancer.

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Abstract

CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein of mucin family glycoprotein that is encoded by the MUC16 gene. It is the most frequently used biomarker for ovarian cancer. It may also be elevated in other cancers, including endometrium, fallopian tube, lung, breast and gastrointestinal cancer and in a number of relatively benign conditions, such as endometriosis, menstruation and pregnancy. High plasma levels of more than 200 U/mL are usually suggestive of malignancy but rarely found in benign conditions of female genital tract, like endometriosis. Very high CA- 125 level is suggestive of ovarian malignancy, was noted in case of ovarian endometrioma. This paper describes a case of a 36 years old lady, mother of 2 children, was admitted with large abdominal mass and abdominal pain. CA-125 was found 3500 U/ML. Ovarian malignancy was suspected. During laparotomy, ruptured endometrioma was noted and it was supported by histopathological report which mentioned," No malignancy seen". Endometrioma can't be excluded in high CA-125 level even without features of endometriosis.KYAMC Journal Vol. 9, No.-3, October 2018, Page 139-140
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High CA-125 in Endometrioma: An Unusual Presentation DOI: https://doi.org/10.3329/kyamcj.v9i3.38788Keywords: Ovarian endometrioma, CA-125, Ovarian malignancyAbstract CA-125 (cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) also known as mucin 16 or MUC16 is a protein of mucin family glycoprotein that is encoded by the MUC16 gene. It is the most frequently used biomarker for ovarian cancer. It may also be elevated in other cancers, including endometrium, fallopian tube, lung, breast and gastrointestinal cancer and in a number of relatively benign conditions, such as endometriosis, menstruation and pregnancy. High plasma levels of more than 200 U/mL are usually suggestive of malignancy but rarely found in benign conditions of female genital tract, like endometriosis. Very high CA- 125 level is suggestive of ovarian malignancy, was noted in case of ovarian endometrioma. This paper describes a case of a 36 years old lady, mother of 2 children, was admitted with large abdominal mass and abdominal pain. CA-125 was found 3500 U/ML. Ovarian malignancy was suspected. During laparotomy, ruptured endometrioma was noted and it was supported by histopathological report which mentioned," No malignancy seen". Endometrioma can't be excluded in high CA-125 level even without features of endometriosis. KYAMC Journal Vol. 9, No.-3, October 2018, Page 139-140 Downloads 281 244

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