Modulation of pain and hyperalgesia from the urinary tract by algogenic conditions of the reproductive organs in women
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This study investigated how algogenic conditions in the reproductive organs affect pain and hyperalgesia originating from the urinary tract in women.
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Abstract
This study investigated the impact of algogenic conditions of the reproductive organs upon urinary pain perception in women. A 5-year survey was conducted among 69 fertile women with calculosis of one upper urinary tract via an ad-hoc questionnaire. At both retrospective (3 years) and prospective (2 years) investigation, dysmenorrheic women (D) reported more colics than non-dysmenorrheic women (ND) (P<0.001) and women with previous dysmenorrhea treated with estroprogestins (DH)(P<0.05). Pain thresholds (electrical stimulation) of the oblique musculature ipsilateral to the stone (L1, site of referred hyperalgesia from upper urinary tract) were lower in D than in ND (P<0.01) and DH (P<0.05). Calculosis women with asymptomatic endometriosis / ovarian cysts also reported more colics (6-month prospective study) and greater threshold lowering (P<0.05) than women with calculosis alone. The results show enhancement of urinary pain / hyperalgesia by both manifest and latent algogenic conditions of the female reproductive organs. This enhancement could derive from neuronal sensitization in spinal segments of common projection of the two visceral districts (T10-L1).
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Cited by (26)
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- Pelvic organ cross-talk: A new paradigm for endometriosis-related pelvic pain? 2018
- Endometriosis and Sexuality 2017
- Chronic pelvic pain 2015
- Dinitrosyl Iron Complexes with Glutathione Suppress Surgically Induced Experimental Endometriosis in Rats 2015
- Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis 2015
- Chronic Abdominal Pain of Gynecologic Causes: Diagnosis and Treatment 2014
- Peripheral changes in endometriosis-associated pain 2014
- Endometriosis-associated pain syndrome: a nurse-led approach 2013
- Endometriosis: pathogenesis and treatment 2013
- Effects of tramadol on viscero‐visceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis 2013
- Neuroendocrine Aspects of Endometriosis‐Associated Pain 2011
- Priorities for Endometriosis Research: A Proposed Focus on Deep Dyspareunia 2010
- Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications 2010
- Pelvic pain and surgeries in women before interstitial cystitis/painful bladder syndrome 2009
- Women and visceral pain: Are the reproductive organs the main protagonists? Mini‐review at the occasion of the “European Week Against Pain in Women 2007” 2008
- Algies pelviennes chroniques de la femme. Orientation diagnostique et conduite à tenir 2006
- Opposing viscerovisceral effects of surgically induced endometriosis and a control abdominal surgery on the rat bladder 2006
- Algias pélvicas crónicas de la mujer. Orientación diagnóstica y conducta que se debe seguir 2006
- Quality of sex life in women with endometriosis and deep dyspareunia 2005
- The Pains of Endometriosis 2005
- Chronic Pelvic Pain 2003
- Chronic Pelvic Pain: An Integrated Approach to Diagnosis and Treatment 2003
- Influence of endometriosis on pain behaviors and muscle hyperalgesia induced by a ureteral calculosis in female rats 2002
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