[Comparative characteristics of endometrial and endometriosis cell cultures]

Strizhakov An, A N Strizhakov, Vishnevskaia LG, L G Vishnevskaia, Grinberg KN, K. N. Grinberg, Ademian LV, L V Ademian
Biulleten' eksperimental'noi biologii i meditsiny · 1977 · doi:10.1007/bf00802815 · PMID:558011
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-14 ⓘ

This study developed methods to cultivate endometrial and endometriosis cells, finding epithelioid cells in normal endometrium and mixed populations in endometriosis foci, with no clear morphological or growth distinctions post-treatment.

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The paper examines embryotoxic and teratogenic outcomes in pregnant rats after combined intragastric administration of methylurea and sodium nitrite, attributing the effects to endogenous synthesis of nitrosomethylurea. It reports that ascorbic acid and urotropin completely blocked the observed embryotoxicity and teratogenicity, sodium sulfamate partially reduced both effects, and urea did not prevent embryo harm. The main limitation is that the presented results focus on an in vivo pregnancy model and on chemical inhibition of nitrosamine-mediated toxicity rather than on characterization of disease-relevant cellular phenotypes. Relevance to endometriosis: endometriosis is not discussed in the provided text; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The authors studied comparatively the endometrium and endometrosis cell cultures of 35 women before and (in part of the group) after the synthetic progestin treatment. Methods for cultivating the endometrium and endometriosis cells were developed. A normal endometrium cell culture was found to be made up by epithelioid cells, while the cell culture from the endometriosis focus exhibited mostly a mixed cell population. The analysis of the internal endometriosis cell cultures before and after the infecundin treatment failed to show any clear distinction in respect to the cell growth and morphology. Endometriosis cells were found to possess low mitotic activity which made the kariotype studies difficult. the data obtained are the result of the first effort to cultivate endometriosis cells.
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Abstract After combined intragastric administration of methylurea (MU) and sodium nitrite (SN) into rats on the ninth day of pregnancy death of the embryos and a teratogenic effect were observed, due to the endogenous synthesis of nitrosomethylurea, which has a pathogenic effect. Ascorbic acid and urotropin completely blocked the embryotoxic and teratogenic effects observed after combined injection of MU and SN. Sodium sulfamate reduced the embryotoxic effect considerably and the teratogenic effect to some extent, whereas urea did not prevent the manifestation of the harmful action of MU and SN on the embryo. Similar content being viewed by others Literature Cited V. A. Aleksandrov, Vopr. Onkol., No. 12, 76 (1974). V. A. Aleksandrov (V. A. Alexandrov) et al., Experientia,27, 538 (1971). M. C. Archer, S. R. Tannenbaum, T. Y. Fan, et al., J. Nat. Cancer Inst.,54, 1203 (1975). C. A. Bunton, H. Dahn, and L. Loewe, Nature,183, 163 (1959). M. Greenblatt, J. Nat. Cancer Inst.,50, 1055 (1973). S. Ivankovic and R. Preussmann, Naturwissenschaften,57, 460 (1970). S. Ivankovich, W. J. Zeller, D. Schmähl, et al., Naturwissenschaften,60, 525 (1973). S. S. Mirvish, J. Nat. Cancer Inst.,46, 1183 (1971). S. S. Mirvish, M. Greenblatt, and V. R. C. Kommineni, J. Nat. Cancer Inst.,48, 1311 (1972). S. S. Mirvish and C. Chu, J. Nat. Cancer Inst.,50, 745 (1973). S. S. Mirvish, L. Wallcave, M. Eagen, and P. Shubik, Science,177, 64 (1972). R. Montesano and P. N. Magee, Int. J. Cancer,7, 249 (1971). G. Osske, R. Warzok, and J. Schneider, Arch. Geschwulstforsch.,40, 244 (1972). M. Rustia, Cancer Res.,34, 3232 (1974). J. Sander, Arzneim. Forsch.,21, 1707 (1971). Rights and permissions About this article Cite this article Aleksandrov, V.A., Dzhioev, F.K. Inhibition of the embryotoxic and teratogenic effects of methylurea and sodium nitrite by various substances. Bull Exp Biol Med 83, 88–90 (1977). https://doi.org/10.1007/BF00802815 Received: Issue date: DOI: https://doi.org/10.1007/BF00802815

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Condition tags

endometriosis

MeSH descriptors

Cells, Cultured Endometriosis Endometriosis Endometrium Adult Animals Chromosomes Female Humans Methods Mitosis Ovarian Neoplasms Uterine Neoplasms

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