{"paper_id":"2b03287c-f456-46fe-9d5f-85ef0a2ed328","body_text":"Abstract\nAfter combined intragastric administration of methylurea (MU) and sodium nitrite (SN) into rats on the ninth day of pregnancy death of the embryos and a teratogenic effect were observed, due to the endogenous synthesis of nitrosomethylurea, which has a pathogenic effect. Ascorbic acid and urotropin completely blocked the embryotoxic and teratogenic effects observed after combined injection of MU and SN. Sodium sulfamate reduced the embryotoxic effect considerably and the teratogenic effect to some extent, whereas urea did not prevent the manifestation of the harmful action of MU and SN on the embryo.\nSimilar content being viewed by others\nLiterature Cited\nV. A. Aleksandrov, Vopr. Onkol., No. 12, 76 (1974).\nV. A. Aleksandrov (V. A. Alexandrov) et al., Experientia,27, 538 (1971).\nM. C. Archer, S. R. Tannenbaum, T. Y. Fan, et al., J. Nat. Cancer Inst.,54, 1203 (1975).\nC. A. Bunton, H. Dahn, and L. Loewe, Nature,183, 163 (1959).\nM. Greenblatt, J. Nat. Cancer Inst.,50, 1055 (1973).\nS. Ivankovic and R. Preussmann, Naturwissenschaften,57, 460 (1970).\nS. Ivankovich, W. J. Zeller, D. Schmähl, et al., Naturwissenschaften,60, 525 (1973).\nS. S. Mirvish, J. Nat. Cancer Inst.,46, 1183 (1971).\nS. S. Mirvish, M. Greenblatt, and V. R. C. Kommineni, J. Nat. Cancer Inst.,48, 1311 (1972).\nS. S. Mirvish and C. Chu, J. Nat. Cancer Inst.,50, 745 (1973).\nS. S. Mirvish, L. Wallcave, M. Eagen, and P. Shubik, Science,177, 64 (1972).\nR. Montesano and P. N. Magee, Int. J. Cancer,7, 249 (1971).\nG. Osske, R. Warzok, and J. Schneider, Arch. Geschwulstforsch.,40, 244 (1972).\nM. Rustia, Cancer Res.,34, 3232 (1974).\nJ. Sander, Arzneim. Forsch.,21, 1707 (1971).\nRights and permissions\nAbout this article\nCite this article\nAleksandrov, V.A., Dzhioev, F.K. Inhibition of the embryotoxic and teratogenic effects of methylurea and sodium nitrite by various substances. Bull Exp Biol Med 83, 88–90 (1977). https://doi.org/10.1007/BF00802815\nReceived:\nIssue date:\nDOI: https://doi.org/10.1007/BF00802815","source_license":"public-domain-us","license_restricted":false}