Use of knockout transgenic mice in the study of endometriosis: insights from mice lacking β2-microglobulin and interleukin-12p40
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This study utilized knockout mice lacking β2-microglobulin and interleukin-12p40 to investigate their roles in the development and progression of endometriosis.
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Abstract
ObjectiveTo test the possibility of using transgenic knockout mice in the study of endometriosis and to investigate specific immunologic aspects of the disease.DesignExperimental blinded study.SettingAcademic research center.Animal(s)Thirty-two mice with experimentally induced endometriosis.Intervention(s)Endometriosis was induced in 8 beta(2)-microglobulin-deficient BALB/c mice and 7 wild-type BALB/c controls. Similarly, endometriosis was induced in 8 interleukin-12-deficient C57BL/6 mice and in 9 wild-type C57BL/6 controls.Main outcome measure(s)Weight and surface area of endometriotic lesions.Result(s)Total weight and surface area of endometriotic lesions was markedly lower in beta(2)-microglobulin-deficient BALB/c mice than in wild-type BALB/c controls. A slight but statistically insignificant increase in total weight and surface area of lesions was observed in interleukin-12-deficient C57BL/6 mice compared to wild-type C57BL/6 controls.Conclusion(s)Knockout transgenic mice can be used successfully for the study of endometriosis; however, in these animals, the redundancy of the immunologic cytokine-mediated regulatory mechanisms may lead to compensation from the remaining genome. Results from beta(2)-microglobulin-deficient mice support the critical role of the immune system in the pathogenesis of the disease.
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References (5)
- Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis via openalex
- Interleukin-12 and Its Free p40 Subunit Regulate Immune Recognition of Endometrial Cells: Potential Role in Endometriosis<sup>1</sup> via openalex
- W1990653743 via openalex
- W2010724066 via openalex
- W2020086511 via openalex
Cited by (17)
- A role for gut mycobiome and altered fungal-bacterial interactions in women with endometriosis† 2025
- Identification of distinct stool metabolites in women with endometriosis for non-invasive diagnosis and potential for microbiota-based therapies 2024
- Changing prostaglandin E2 (PGE<sub>2</sub>) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE<sub>2</sub> receptor EP2 and EP4 2021
- Preoperative and perioperative intervention reduces the risk of recurrence of endometriosis in mice caused by either incomplete excision or spillage and dissemination 2021
- Early maternal separation accelerates the progression of endometriosis in adult mice 2020
- Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells 2020
- Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis 2020
- Perioperative Intervention by β-Blockade and NF-κB Suppression Reduces the Recurrence Risk of Endometriosis in Mice Due to Incomplete Excision 2019
- Crocin improves endometriosis by inhibiting cell proliferation and the release of inflammatory factors 2018
- Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β<sub>2</sub> 2016
- Progressive development of endometriosis and its hindrance by anti-platelet treatment in mice with induced endometriosis 2016
- Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence 2015
- Endometriosis, a disease of the macrophage 2013
- Proangiogenic Tie2+ Macrophages Infiltrate Human and Murine Endometriotic Lesions and Dictate Their Growth in a Mouse Model of the Disease 2011
- Macrophages Are Alternatively Activated in Patients with Endometriosis and Required for Growth and Vascularization of Lesions in a Mouse Model of Disease 2009
- Quantification of endometriotic lesions in a murine model by fluorimetric and morphometric analyses 2005
- Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis 2002
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- europepmc
- last seen: 2026-07-26T06:08:39.051465+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
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- unpaywall
- last seen: 2026-06-13T06:42:57.164913+00:00
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