Near-complete magnetic resonance-guided high-intensity focused ultrasound ablation of adenomyosis impact on safety aspects

Interventional non-vascular, MR, Ablation procedures, Obstetrics Authors: N. Minh Duc1, D. Vinh Hiep1, H. Quang Huy1, B. Keserci2; 1Ho Chi Minh/VN, 2Kelantan/MY DOI: 10.26044/ranzcr2019/R-0001 Purpose We aimed to investigate the impact of near-complete magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) ablation of adenomyosis with a non-perfused volume ratio (NPVr) ≥ 90% on safety aspects.

and materials This retrospective study was approved by institutional review board. Sixty-six women who underwent HIFU treatment were divided into groups A (NPVr ≥ 90%; n = 26) and B (NPVr < 90%, n = 40). Multivariate logistic regression analyses of MRI features were conducted to identify the potential predictors of an NPVr ≥ 90%. The parameters of safety aspects were defined as adverse events and serum Anti-Mullerian Hormone (AMH). We also utilized the Generalized estimating equation (GEE) to produce the logistic prediction model of NPVr ≥...

Generalized estimating equation (GEE) generated logistic equation of NPVr ≥ 90%: y = eq / (1 + eq) with q = –0.130 – 0.03x1 – 0.025x2 + 0.839x3 + 4.862x4 where where x1 = thickness of the subcutaneous fat layer (millimeters), x2 = adenomyosis volume (ml), x3 = T2 SI ratio of adenomyosis to myometrium, and x4 = Ktrans ratio of adenomyosis to myometrium in predicting the probability of NPV ≥ 90%. There were no significant differences in adverse events between two groups. By means...

The results revealed that the achievement of NPVr ≥ 90% in MRIgHIFU of adenomyosis did not produce a negative effect on the safety aspects but generated better outcomes for the patients. Personal information Nguyen Minh Duc, MD Department of Radiology Pham Ngoc Thach University of Medicine 02 Duong Quang Trung Ward 12 District 10 Ho Chi Minh city Vietnam Email: [email protected]

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