{"paper_id":"2ac1521f-81ec-4166-9734-aed6492524e9","body_text":"2019 ASM / R-0001\nNear-complete magnetic resonance-guided high-intensity focused ultrasound ablation of adenomyosis impact on safety aspects\nCongress:\n2019 ASM\nPoster Number:\nR-0001\nType:\nScientific Exhibit\nKeywords:\nInterventional non-vascular, MR, Ablation procedures, Obstetrics\nAuthors:\nN. Minh Duc1, D. Vinh Hiep1, H. Quang Huy1, B. Keserci2; 1Ho Chi Minh/VN, 2Kelantan/MY\nDOI:\n10.26044/ranzcr2019/R-0001\nPurpose\nWe aimed to investigate the impact of near-complete magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) ablation of adenomyosis with a non-perfused volume ratio (NPVr) ≥ 90% on safety aspects.\nMethods and materials\nThis retrospective study was approved by institutional review board. Sixty-six women who underwent HIFU treatment were divided into groups A (NPVr ≥ 90%; n = 26) and B (NPVr < 90%, n = 40). Multivariate logistic regression analyses of MRI features were conducted to identify the potential predictors of an NPVr ≥ 90%. The parameters of safety aspects were defined as adverse events and serum Anti-Mullerian Hormone (AMH). We also utilized the Generalized estimating equation (GEE) to produce the logistic prediction model of NPVr ≥...\nResults\nGeneralized estimating equation (GEE) generated logistic equation of NPVr ≥ 90%: y = eq / (1 + eq) with q = –0.130 – 0.03x1 – 0.025x2 + 0.839x3 + 4.862x4 where where x1 = thickness of the subcutaneous fat layer (millimeters), x2 = adenomyosis volume (ml), x3 = T2 SI ratio of adenomyosis to myometrium, and x4 = Ktrans ratio of adenomyosis to myometrium in predicting the probability of NPV ≥ 90%. There were no significant differences in adverse events between two groups. By means...\nConclusion\nThe results revealed that the achievement of NPVr ≥ 90% in MRIgHIFU of adenomyosis did not produce a negative effect on the safety aspects but generated better outcomes for the patients.\nPersonal information\nNguyen Minh Duc, MD\nDepartment of Radiology\nPham Ngoc Thach University of Medicine\n02 Duong Quang Trung Ward 12 District 10 Ho Chi Minh city Vietnam\nEmail: [email protected]\nReferences\nKeserciB,DucNM.Magnetic resonance imaging parameters in predicting the treatment outcome of high-intensity focused ultrasound ablation of uterine fibroids with an immediate nonperfused volume ratio of at least 90%. Acad Radiol. 2018;25:1257-1269\nKeserciB,DucNM.The role of T1 perfusion-based classification in predicting the outcome of magnetic resonance-guided high-intensity focused ultrasound treatment of adenomyosis. Int J Hyperthermia.2018;34:306–314.\nFukunishiH,FunakiK,SawadaK, etal.Early results of magnetic resonance-guided focused ultrasound surgery of adenomyosis: analysis of 20 cases. J Minim Invasive Gynecol.2008;15:571–579.\nZhouM,ChenJY,TangLD, etal.Ultrasound-guided high-intensity focused ultrasound ablation for adenomyosis: the clinical experience of a single...","source_license":"CC0","license_restricted":false}