Effect of tibolone on postmenopausal women with myomas

O. Gregoriou, Odysseas Gregoriou, N. Vitoratos, Nicolaos Vitoratos, Constantinos B. Papadias, C Papadias, Sokratis Konidaris, S. Konidaris, D Costomenos, Dimitrios Costomenos, A. Chryssikopoulos
Maturitas · 1997 · vol. 27(2) , pp. 187–191 · doi:10.1016/s0378-5122(97)00036-4 · PMID:9255754 · W2150942808
RCT OA: closed CC0 ⤵ 4 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study investigated the effects of tibolone on postmenopausal women experiencing myomas and found that tibolone treatment did not significantly alter myoma size.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

OBJECTIVE: The aim of this study is to assess the effect of Tibolone (Livial) on uterine fibroids in postmenopausal women. METHODS: This study included 40 naturally postmenopausal women with at least one uterine fibroid measuring > 20 mm. All of theme were scanned by transvaginal ultrasonography. Patients were randomized into two groups. Group A (n = 20) were treated with Tibolone 2.5 mg daily for 1 year and group B (n = 20) did not received therapy. The size of the uterine fibroids was reevaluated on the end of the treatment. RESULTS: No statistically significant difference was found in the mean volume of fibroids before and after treatment with Tibolone. The administration of Tibolone resulted in an increase of fibroid volume in three patients, whereas it remained constant in the majority of the patients (70%) and decreased in three patients. CONCLUSIONS: Our results suggest that treating menopausal symptoms with Tibolone does not affect preexisting asymptomatic uterine fibroids.

My notes (saved in your browser only)

MeSH descriptors

Anabolic Agents Estrogen Replacement Therapy Leiomyoma Norpregnenes Postmenopause Uterine Neoplasms Anabolic Agents Anabolic Agents Estrogen Replacement Therapy Female Humans Leiomyoma Leiomyoma Norpregnenes Norpregnenes Postmenopause Postmenopause Ultrasonography Uterine Neoplasms Uterine Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (11)

Cited by (5)

Source provenance

openalex
last seen: 2026-05-11T06:03:29.626429+00:00
pubmed
last seen: 2026-10-08T22:00:22.376048+00:00
unpaywall
last seen: 2026-10-13T06:25:51.201866+00:00
License: CC0 · commercial use OK