Effect of tibolone on postmenopausal women with myomas

Odysseas Gregoriou; Nicolaos Vitoratos; Constantinos B. Papadias; Sokratis Konidaris; Dimitrios Costomenos; A. Chryssikopoulos

doi:10.1016/s0378-5122(97)00036-4

Effect of tibolone on postmenopausal women with myomas

Odysseas Gregoriou, Nicolaos Vitoratos, Constantinos B. Papadias, Sokratis Konidaris, Dimitrios Costomenos, A. Chryssikopoulos

In: Maturitas · 1997 · vol. 27(2) , pp. 187–191 · doi:10.1016/s0378-5122(97)00036-4 · PMID:9255754 · W2150942808

article OA: closed CC0 ⤵ 4 in-corpus citations

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This study investigated the effects of tibolone on postmenopausal women experiencing myomas and found that tibolone treatment did not significantly alter myoma size.

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Abstract

ObjectiveThe aim of this study is to assess the effect of Tibolone (Livial) on uterine fibroids in postmenopausal women.MethodsThis study included 40 naturally postmenopausal women with at least one uterine fibroid measuring > 20 mm. All of theme were scanned by transvaginal ultrasonography. Patients were randomized into two groups. Group A (n = 20) were treated with Tibolone 2.5 mg daily for 1 year and group B (n = 20) did not received therapy. The size of the uterine fibroids was reevaluated on the end of the treatment.ResultsNo statistically significant difference was found in the mean volume of fibroids before and after treatment with Tibolone. The administration of Tibolone resulted in an increase of fibroid volume in three patients, whereas it remained constant in the majority of the patients (70%) and decreased in three patients.ConclusionsOur results suggest that treating menopausal symptoms with Tibolone does not affect preexisting asymptomatic uterine fibroids.

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References (11)

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doi:10.1007/bf01606522 via openalex
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[1] COMPARISON OF CELLULAR LEVELS OF STEROID RECEPTORS IN UTERINE LEIOMYOMA AND MYOMETRIUM via openalex

[2] doi:10.1007/bf01606522 via openalex

[3] doi:10.1016/0002-9378(79)90716-6 via openalex

[4] doi:10.1016/s0015-0282(16)45789-4 via openalex

[5] doi:10.1016/s0015-0282(16)58098-4 via openalex

[6] doi:10.1016/0002-9378(58)90848-2 via openalex

[7] doi:10.3109/00016348309154224 via openalex

[8] doi:10.1530/jrf.0.0020098 via openalex

[9] W2400463702 via openalex

[10] doi:10.1055/s-2007-1018893 via openalex

[11] doi:10.1016/0020-7292(90)90913-6 via openalex