The relationship between uterine prolapse and premalignant endometrial pathology

Genc M, Mine Genç, M Genc, Zeliha Esin Çelik, E Celik, F. Eskicioglu, Eskicioglu F, Bahar Gur E, E Bahar Gur, Esra Bahar Gür, Seçil Kurtulmuş, Kurtulmus S, S Kurtulmus, E. Gulec, Gulec E, S. Guclu, Guclu S
Clinical and experimental obstetrics & gynecology · 2016 · vol. 43(4) , pp. 500–503 · doi:10.12891/ceog2095.2016 · PMID:29734535 · W2998176817
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This study found that a significant proportion of women with uterine prolapse who underwent hysterectomy had premalignant endometrial lesions, suggesting a link between prolapse and endometrial pathology.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-16 · read from full text ⓘ

This study evaluated 111 patients with grades 3–4 uterine prolapse who underwent hysterectomy, assessing whether histopathology revealed premalignant or other pathologic endometrial findings in women with no additional complaints. Post-hysterectomy results were classified as benign versus pathologic, with pathologic findings including endometrial hyperplasia (20.2%), endometrial polyps (7.2%), uterine fibroids (27%), and adenomyosis (18%). The authors conclude that premalignant endometrial lesions can occur in both premenopausal and postmenopausal women presenting with uterine prolapse without other symptoms, proposing that chronic inflammation related to the extra-vaginal uterine position may contribute, while noting that further studies are needed. Relevance to endometriosis: adenomyosis was reported among the pathologic histopathology findings, making this paper relevant to uterine conditions related to endometriosis/adenomyosis overlap.

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Abstract

OBJECTIVE: The aim of this study was to stress the importance of performing a thorough uterine assessment before selecting an organ- sparing surgery in patients presenting with uterine prolapse and no other complaints. MATERIALS AND METHODS: This study included a total of 111 participants who presented with pelvic organ prolapse and underwent hysterectomy for grades 3-4 uterine prolapse. The posthysterectomy histopathology results were classified as benign (atrophic endometrium, proliferative or secretory endometrium) or pathologic (endometrial hyperplasia, endometrial polyp, adenomyosis, myoma uteri, and endometrium carcinoma). RESULTS: Of the 111 patients enrolled in this study, 23 (20.2%) had endometrial hyperplasia, eight (7.2%) had endometrial polyps, 30 (27%) had uterine fibroids, and 20 (18%) had adenomyosis. CONCLUSION: There may be premalignant lesions of the endometrium in both premenopausal and postmenopausal women presenting with uterine prolapse and no other symptoms. A chronic inflammatory process resulting from the extra-vaginal location of the uterus may play a role in the development of these lesions. Further studies are needed on this subject.
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Abstract

Objective: The aim of this study was to stress the importance of performing a thorough uterine assessment before selecting an organsparing surgery in patients presenting with uterine prolapse and no other complaints. Materials and Methods: This study included a total of 111 participants who presented with pelvic organ prolapse and underwent hysterectomy for grades 3-4 uterine prolapse. The posthysterectomy histopathology results were classified as benign (atrophic endometrium, proliferative or secretory endometrium) or pathologic (endometrial hyperplasia, endometrial polyp, adenomyosis, myoma uteri, and endometrium carcinoma). Results: Of the 111 patients enrolled in this study, 23 (20.2%) had endometrial hyperplasia, eight (7.2%) had endometrial polyps, 30 (27%) had uterine fibroids, and 20 (18%) had adenomyosis. Conclusion: There may be premalignant lesions of the endometrium in both premenopausal and postmenopausal women presenting with uterine prolapse and no other symptoms. A chronic inflammatory process resulting from the extra-vaginal location of the uterus may play a role in the development of these lesions. Further studies are needed on this subject.

Keywords

- Uterine prolapse - Hysterectomy - Endometrial hyperplasia

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Condition tags

adenomyosis

MeSH descriptors

Endometrial Neoplasms Endometrial Neoplasms Uterine Prolapse Adenomyosis Adenomyosis Adult Aged Endometrial Neoplasms Endometrial Neoplasms Female Humans Hysterectomy Leiomyoma Leiomyoma Leiomyoma Middle Aged Polyps Polyps Precancerous Conditions Precancerous Conditions

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