Risks with Danazol in the Acquired Immunodeficiency Syndrome

Letters and Corrections1 October 1984Risks with Danazol in the Acquired Immunodeficiency SyndromeCRAIG E. METROKA, M.D., PH.D., ANNE MOORE, M.D., JOSEPH A. SONNABEND, M.B., SUSANNA CUNNINGHAM-RUNDLES, PH.D.CRAIG E. METROKA, M.D., PH.D.Search for more papers by this author, ANNE MOORE, M.D.Search for more papers by this author, JOSEPH A. SONNABEND, M.B.Search for more papers by this author, SUSANNA CUNNINGHAM-RUNDLES, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-4-564_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Recently, danazol (Danocrine; Winthrop Laboratories, New York, New York) has been reported to decrease the need for transfusions of plasma products in persons with classic hemophilia and hemophilia B (Christmas disease) (1), to increase the platelet count in patients with autoimmune thrombocytopenic purpura (2), and to restore the T4/T8 ratio and lymphoproliferative responses to normal in patients with autoimmune thrombocytopenic purpura (3; FISCHL M. Personal communication.). These observations prompted us to examine the possibility that danazol might be able to improve T-cell function in patients with untreated Kaposi's sarcoma and persons who had clinically recovered from an...References1. GRALNICKRICK HM. Danazol increases factor VIII and factor IX in classic hemophilia and Christmas disease. N Engl J Med. 1983;308:1393-5. CrossrefMedlineGoogle Scholar2. AHNHARRINGTONSIMON YWS. Danazol for the treatment of idiopathic thrombocytopenic purpura. N Engl J Med. 1983;308:1396-9. CrossrefMedlineGoogle Scholar3. AHNHARRINGTONMYLVAGANAM YWR. Danazol therapy restores helper/surrpessor (T4/T8) ratios in patients with idiopathic thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA) [Abstract]. Blood. 1983;62:241a. MedlineGoogle Scholar4. METROKACUNNINGHAM-RUNDLESPOLLACK CSM. Generalized lymphadenopathy in homosexual men. Ann Intern Med. 1983;99:585-91. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByHemostatic Abnormalities in HIV DiseaseDetermination of Danazol in Plasma by High Performance Liquid ChromatographyHuman Immunodeficiency Virus-Associated ThrombocytopeniaMANAGEMENT OF HUMAN IMMUNODEFICIENCY VIRUS-INDUCED THROMBOCYTOPENIA IN HEMOPHILIADrug Information Analysis Service 1 October 1984Volume 101, Issue 4Page: 564-565KeywordsAIDSBlood plasmaHemophilia AHemophilia BIdiopathic thrombocytopenic purpuraKaposi sarcomaPlateletsRisk management Issue Published: 1 October 1984 PDF DownloadLoading ...