Intestinal and pelvic endometriosis presenting as a tumor and associated with tamoxifen therapy: Report of a case

Leila R. Hajjar, WooShin Kim, George H. Nolan, Sharon Turner, Usha R. Raju
In: Obstetrics & Gynecology · 1993 · vol. 82(4) , pp. 642–644 · doi:10.1097/00006250-199310000-00032 · W4240440374
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A 50-year-old woman developed extensive tumor-like endometriosis requiring surgery after two years of adjuvant tamoxifen therapy for breast cancer.

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This case report describes a 50-year-old postmenopausal woman who developed extensive tumor-like intestinal and pelvic endometriosis after receiving two years of adjuvant tamoxifen therapy for breast carcinoma. Although tamoxifen is primarily used for its antiestrogenic properties, it exhibits estrogenic effects that may stimulate the growth of endometrial tissue outside the uterus. The patient required extensive surgical intervention to remove the lesions, highlighting the potential gynecological complications associated with this medication. This paper is centrally about endometriosis — specifically, the presentation of deep infiltrating disease as a tumor mass in a patient undergoing hormonal therapy.

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Abstract

Background: Tamoxifen has been used in the adjuvant treatment of breast cancer because of its antiestrogenic effects. However, recent reports have shown it to have estrogenic effects as well. The purpose of this report is to describe a potential association between tamoxifen therapy and endometriosis. Case: A 50-year-old postmenopausal woman who had received 2 years of adjuvant tamoxifen therapy for breast carcinoma developed extensive tumor-like endometriosis necessitating extensive pelvic and intestinal surgery. Conclusion: This case report highlights the need for obstetricians and gynecologists to be familiar with the actions of tamoxifen and its potential complications.(Obstet Gynecol 1993;82:642-4)
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Background

Tamoxifen has been used in the adjuvant treatment of breast cancer because of its antiestrogenic effects. However, recent reports have shown it to have estrogenic effects as well. The purpose of this report is to describe a potential association between tamoxifen therapy and endometriosis. Case: A 50-year-old postmenopausal woman who had received 2 years of adjuvant tamoxifen therapy for breast carcinoma developed extensive tumor-like endometriosis necessitating extensive pelvic and intestinal surgery.

Conclusion

This case report highlights the need for obstetricians and gynecologists to be familiar with the actions of tamoxifen and its potential complications.(Obstet Gynecol 1993;82:642-4) Copyright © 1993 The American College of Obstetricians and Gynecologists

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endometriosis

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